Automated method and apparatus for preparing bioprocess solutions

An automated method, comprising:

• providing a dry ingredient to be reconstituted into a liquid bioprocess solution;
• providing an automated system comprising at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and one or more inlets to the tubing;
• coupling a purified water source to one of the one or more inlets;
• and
• controlling, by a processing circuit, the automated system to prepare a liquid bioprocess solution from the dry ingredient by:
• performing a series of sequential mixing steps, wherein the series of sequential mixing steps comprises, at least:
• opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and
• after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port;
• and
• taking one or more measurements during the preparation of the liquid bioprocess solution;
• wherein each step is triggered by at least one of a measurement decreasing below, equaling, or exceeding a measurement threshold.