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US 11,097,020 B2Granted
Methods and compositions for targeted delivery
AssigneeSignablok, Inc.
InventorAlexander B. Sigalov
Life of this patent
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Abstract
The disclosure provides compounds and compositions, and methods of using these compounds and compositions, for the targeted delivery of therapeutic agents. In one embodiment, these compositions are used for the tumor-targeted delivery of chemotherapeutic agents useful for treating cancer.
Claims40
A composition comprising a reconstituted lipoprotein nanoparticle comprising;
- i) a plurality of phospholipids;
- ii) at least one apolipoprotein comprising a modification, wherein said modification comprises one or two sulfoxidized methionine residues and not a modified tyrosine residue;
- and
- iii) at least one therapeutic agent attached to said nanoparticle.
1 more element
A composition, comprising a reconstituted lipoprotein nanoparticle comprising,
- i) a triglyceride-cholesterol ester core surrounded by a plurality of phospholipids;
- ii) at least one apolipoprotein comprising a modification, wherein said modification comprises one or two sulfoxidized methionine residues and nota modified tyrosine residue;
- and
- iii) at least one therapeutic agent attached to said nanoparticle.
1 more element
Dependencies are inferred from the claim text.