Scaffolds for cell transplantation
AssigneesPresident and Fellows of Harvard College, The Regents of the University of Michigan
InventorsDavid J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
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Abstract
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
Claims43
An injectable or implantable device for modulating immune cell activity in a subject comprising:
- a scaffold composition comprising a polymer matrix and having open, interconnected macropores, wherein the scaffold composition temporally controls egress of resident immune cells;
- a recruitment composition that recruits an immune cell to the scaffold composition in the body of the subject;
- a bioactive composition that modulates the activity of the immune cell, wherein the modulated immune cells migrate to another site in the body after said modulation;
- and
- a deployment signal that induces egress of the immune cell from the scaffold composition to migrate to another site in the body of the subject;
- wherein the bioactive composition modulates the activity of the immune cell while the immune cell resides in the macropores of the scaffold composition in the body of the subject;
- wherein the immune cell is selected from the group consisting of a T cell, a B cell, a macrophage, a dendritic cell, an NK cell, and any combination thereof.
Dependencies are inferred from the claim text.