Use of seaprose to remove bacterial biofilm

A method of disrupting a bacterial biofilm present on a wound that does not include necrotic tissue, the method consisting of applying a composition consisting of seaprose and a pharmaceutically acceptable carrier to the bacterial biofilm present on the wound, wherein seaprose is a semi-alkaline protease produced by the fermentation of the fungus Aspergillus melleus, wherein application of the composition to the bacterial biofilm disrupts the matrix of the bacterial biofilm, wherein the semi-alkaline protease has a molecular weight of about 31 kDa, wherein the pharmaceutically acceptable carrier is selected from a lotion, cream, emulsion, ointment, gel, paste, solution, aerosol spray, aerosol foam, non-aerosol spray, non-aerosol foam, powder, liquid solution, liquid suspension, film, and sheet, and wherein seaprose is the only enzymatic agent in the composition.