Machine for chemical analysis comprising the combination of electron ionization mass spectrometry with liquid chromatography

A chemical analysis machine comprising a liquid phase chromatograph comprising, in turn, a chromatography nano-column with an inner diameter that is smaller than or equal to 100 μm, an electronic ionization mass spectrometer, and a joining assembly interposed between the liquid phase chromatograph and the electronic ionization mass spectrometer;

• said machine being characterized in that said joining assembly comprises a microcapillary tube having an inner diameter smaller than or equal to 50 μm and having a first end, which is directly connected to an outlet end of the nano-column so as to receive the liquid phase, and a second end, which is housed inside a vaporization microcannula within which an inert gas flows;
• said vaporization microcannula being partially engaged by said microcapillary tube and having an end facing the inside of an ionization chamber of said electronic ionization mass spectrometer;
• said vaporization microcannula being divided into a first part, which is subjected to the action of a heating device, adapted to heat said first part to a temperature ranging between 200 and 400° C., and a second part, which is kept at room temperature and has a length that is greater than or equal to 2 cm;
• said microcapillary tube occupying the inside of the entire second part of the vaporization microcannula and having an end portion that is arranged inside said first part and has a length that is less than or equal to 5 mm.