Back to results
US 11,091,776 B2Granted
AAV8 mutant capsids and compositions containing same
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M. Wilson, Qiang Wang
Life of this patent
Estimating the term…
Abstract
Provided herein are AAV8 mutant capsids and rAAV comprising the same. In one embodiment, vectors employing the AAV8 mutant capsid show increased transduction in a selected tissue as compared to AAV8.
Claims12
An adeno-associated virus (AAV) having a capsid comprising a vp3 capsid protein having at least the following mutations, as compared to native AAV8:
- N263S, S266H, T457S, A583G, Q588L, Q589Y, Q594G, I595S, G596V and T597F, wherein the native AAV8 is encoded by SEQ ID NO:
- 34 and wherein the capsid is encoded by SEQ ID NO:
- 17, SEQ ID NO:
- 19 or SEQ ID NO:
- 21, or a sequence sharing at least 80% identity therewith.
2 more elements
Dependencies are inferred from the claim text.