Back to results
US 11,091,437 B2Granted
Aryl isonitriles as a new class of antimicrobial compounds
AssigneePurdue Research Foundation
InventorsMohamed Seleem, Mingji Dai, Dexter Cameron Davis, Haroon Taj Mohammad
Life of this patent
Estimating the term…
Abstract
The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
Claims4
An isonitrile compound having the structure:
- wherein R is a hydrogen, an alkyl, a cycloalkyl, a heteroalkyl, or an aryl group,
- n is an integer from 0 to 4, X is hydrogen, a C1 to C3 alkyl group, a halogen, trihalomethyl, or a nitro group, and W, Y and Z are either each independently —CH—, or two of W, Y and Z are each —CH— and the rest one is —N—, when NC group is at the para or meta position of the linker;
- or wherein R is a cycloalkyl, a heteroalkyl, or an aryl group;
- n is an integer from 0 to 4, X is hydrogen, a C1 to C3 alkyl group, a halogen, alkyloxy, trihalomethyl, or a nitro group, and W, Y and Z are either each independently —CH—, or two of W, Y and Z are each —CH— and the rest one is —N—, when NC group is at the ortho position of the linker,
- or pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.