Methods and compositions to increase immune response to vaccines
AssigneeApplied Biotechnology Institute, Inc.
InventorsJohn Howard, Celine Hayden
Life of this patent
Estimating the term…
Abstract
Methods of vaccination of animals are provided. In an embodiment, a paired administration of a primer vaccine provides for non-oral administration of a vaccine and an oral administration of the vaccine and can be followed by a paired administration of a booster vaccine of a non-oral administration and an oral administration. Embodiments provide the non-oral and oral administration are within three days of each other. The methods provide for improved protective response in an animal compared to administration of a primer non-oral administered vaccine followed by three booster non-oral administered vaccines. An adjuvant is provided that is a microcrystalline polysaccharide-based adjuvant derived from delta inulin.
Claims19
A method of increasing a protective response to a hepatitis B or Coccidioides vaccine, the method comprising, administering to an animal, at least one paired administration of a vaccine comprising a nucleic acid molecule and/or polypeptide of hepatitis B or Coccidioides, said administration comprising an oral administration of said vaccine and a non-oral administration of said vaccine, wherein said oral administration is an oral administration of a composition comprising a plant or plant part comprising said nucleic acid molecule and/or polypeptide, wherein said oral and non-oral vaccines are administered within three days from the other said administration of said vaccines producing an increased protective response compared to an animal not administered said vaccine.
A method of reducing the number of booster vaccinations and protecting an animal from hepatitis B or Coccidioides, the method comprising, administering to an animal,
- i) a priming paired administration of a vaccine comprising a nucleic acid molecule and/or polypeptide of hepatitis B or Coccidioides, said administration comprising an oral administration of said vaccine and a non-oral administration of said vaccine, wherein said oral and non-oral vaccines are administered within three days from the other;
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- ii) a booster paired administration of said vaccine comprising an oral administration of said vaccine and a non-oral administration of said vaccine, wherein said oral and non-oral vaccines are administered within three days from each other,
- wherein said oral administration is an oral administration of a composition comprising a plant or plant part comprising said nucleic acid molecule and/or polypeptide, said method producing the same or an increased protective response compared to administering a primer and two boosting parental administrations of said vaccine.
Dependencies are inferred from the claim text.