Gluten-free grain-concentrate substitute for fermented wheat germ drug product and method preparation

A gluten free grain concentrate produced from only water soluble concentrate, without maltodextrin, auxiliary drying material, drying fermented liquid or boiling off water, comprising 2,6-dimethoxy-1,4-hydroquinone;

• monomethoxy-1,4-benzoquinone;
• and monomethoxy-1,4-hydroquinone;
• prepared by three phased temperature controlled process comprising the steps of:
• (A) a fermentation process comprising:
• a) heating 400 gallons of filtered water to a temperature of 25 C;
• b) adding said water to a vessel containing 100 lbs of crumbled baker's yeast (Saccharomyces cerevisiae);
• c) mixing said yeast water mix constantly for 1 hour;
• d) adding 1,000 lbs of raw wheat germ to said yeast water mix;
• e) continuously stirring said wheat germ yeast water mix for 8 to 10 hours without additional aeration allowing temperature to raise to a temperature of not more than 40 C;
• (B) an active-ingredient extraction process comprising:
• f) decanting said wheat germ yeast water mix through a liquid-solid separator with a 100 to 150-micron screen into a stacked disc centrifuge to initiate liquid-liquid extraction;
• g) operating said stacked disc centrifuge to remove a yeast paste consisting of at least 75% of the yeast from said low wheat germ liquid forming a low yeast liquid, and discarding said yeast paste;
• wherein said low yeast liquid contains only water soluble portion of said wheat germ concentrate;
• h) transferring said low yeast liquid to a plate and frame filtration device with filter plates having one to five-micron openings;
• operating said plate and frame filtration device to produce a clarified broth no more than 7% dissolved solids;
• i) transferring said broth to a vacuum evaporator;
• k) operating said vacuum evaporator to remove water from said broth producing a concentrated broth which has no less than 28% dissolved solids;
• l) transferring said concentrated broth to a second centrifuge;
• m) operating said second centrifuge to remove remaining suspended solids forming a clarified broth;
• n) transferring said clarified broth solid to a third vessel containing sufficient ethyl acetate to remove at least 99.4% of gluten from said clarified broth forming an ethyl acetate liquid layer and a water layer;
• o) decanting said ethyl acetate liquid layer from said third vessel into a fourth vessel;
• p) evaporating said ethyl acetate liquid in said forth fourth vessel forming concentrated ethyl acetate liquid which contain at least 6% solids;
• q) mixing equal amounts of microcrystalline cellulose and hydroxypropyl methylcellulose in sufficient quantities forming a cellulose mix which has a volume of nine times the volume of said concentrated ethyl acetate liquid;
• r) adding said cellulose mix to said concentrated ethyl acetate liquid in said fourth vessel forming final mix;
• (C) a liquid-to-solid transformation process comprising:
• s) pouring said final mix into a vacuum paddle dryer;
• t) setting said vacuum paddle dryer to operate with a vacuum of 26 inches to 28 inches of mercury, a temperature of 30 C-60 C and a 3-60 rpm drum rotation speed;
• u) continuously stirring said final mix with said vacuum paddle dryer for up to 24 hours using said vacuum, heat and drum rotation speed setting forming stable dry powder;
• wherein said three processes require about 72 hours continuously, said 72 hours being comprised of approximately 24 hours of said fermentation process, 24 hours of said active-ingredient extraction process, and approximately 24 hours of drying said liquid-to-solid transformation process.