Methods, tools and systems for the prediction and assessment of gestational diabetes

A genotyping tool for use in a method of assessing Gestational Diabetes Mellitus (GDM) susceptibility in a female human subject, said tool comprising an array having a plurality of oligonucleotide probe pairs, each of said probe pairs comprising a first probe specific for a first allele of a single nucleotide polymorphism (SNP) and a second probe specific for a second allele of the SNP, wherein said plurality of oligonucleotide probe pairs comprises probe pairs that interrogate each of the following SNPs:

• TCF7L2—rs7903146;
• IGF2BP2—rs4402960;
• CDKN2A/B—rs10811661;
• SLC16A11—rs13342232;
• FTO—rs8050136;
• SLC30A8—rs13266634;
• CDC123/CAMK1D—rs12779790;
• KCNQ1—rs2237892;
• CUBN—rs11254363;
• CUBN—rs1801222;
• FIGN—rs2119289;
• FIGN—rs982393;
• MTHFR—rs1801131;
• MTHFR—rs1801133;
• MTR—rs1805087;
• and
• SLC19A1—rs1051266,
• wherein the oligonucleotide probes of the array that interrogate each of the SNPs make up at least 50% of the total number of nucleic acid probes in the array.