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US 11,085,034 B2Granted
Enzyme complex comprising heme polymerase and heme ligase, and method for producing hemozoin using same
AssigneeKorea University Research and Business Foundation
InventorsSung Ok Han, Jeong-Eun Hyeon, Young-jin Ko
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Abstract
The present invention relates to an enzyme complex in which a heme polymerase and a heme ligase are linked to each other via the dockerin module of cellulase, and to a method for producing a hemozoin using the same. The enzyme complex according to the present invention can polymerize heme with higher efficiency than conventional enzymes, and thus can more efficiently produce hemozoin, a conductive biopolymer.
Claims3
An enzyme complex comprising a heme polymerase, a heme ligase, and a scaffold protein,
- wherein the heme polymerase comprises a first dockerin module of a first cellulase, and the heme ligase comprise a second dockerin module of a second cellulase,
- wherein the scaffold protein comprises a cohesin module,
- wherein the heme polymerase and the heme ligase are linked via a protein-protein interaction between the cohesin module, the first dockerin module, and the second dockerin module, and
- wherein the heme polymerase is encoded by the nucleotide sequence set forth in SEQ ID NO:
- 3 and the heme ligase is encoded by the nucleotide sequence set forth in SEQ ID NO:
- 28.
3 more elements
Dependencies are inferred from the claim text.