Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
AssigneeSaint Louis University
InventorsSergio Barranco-Medina, Enrico Di Cera, Nicola Pozzi
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Abstract
Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins and their use as blood anticoagulants and for treating sepsis.
Claims5
A thrombin-thrombomodulin fusion protein comprising a thrombin domain selected from the group consisting of a full-length thrombin polypeptide, a preprothrombin polypeptide, a prothrombin polypeptide, a prethrombin 1 polypeptide, a prethrombin 2 polypeptide, a thrombin A chain, a thrombin B chain, and combinations thereof, wherein the full-length thrombin polypeptide is set forth in SEQ ID NO:3 or SEQ ID NO:5;
- a linker selected from the group consisting of a peptide linker, a chemical linker, and combinations thereof;
- and a thrombomodulin domain selected from the group consisting of a full-length thrombomodulin protein and a thrombomodulin epidermal growth factor-like domain 456 (TM456), wherein the TM456 is set forth in SEQ ID NO:7 or SEQ ID NO:9.
Dependencies are inferred from the claim text.