Nitrogen-containing heterocyclic compound, preparation method, intermediate, pharmaceutical composition and use

A compound of formula I or formula II, a tautomer thereof, an optical isomer thereof, a deuterated compound thereof, a hydrate thereof, a solvate thereof or a pharmaceutically acceptable salt thereof,

• wherein, each of X, Y, X′ and Y′ is independently selected from C or N;
• each of R2 and R′2 is independently hydrogen, a C1-C10 alkyl, a C2-C10 heteroalkyl, a C3-C10 cycloalkyl, a C3-C10 heterocycloalkyl, a C2-C10 alkenyl or a C2-C10 alkynyl;
• wherein, each of the C1-C10 alkyl, the C2-C10 heteroalkyl, the C3-C10 cycloalkyl, the C3-C10 heterocycloalkyl, the C2-C10 alkenyl and the C2-C10 alkynyl is independently substituted by one or more R4;
• when a plurality of R4 substituents are present, the substituents are the same or different;
• R4 is selected from the group consisting of hydrogen, hydroxyl, a halogen, a C1-C6 alkyl, a C3-C10 cycloalkyl and a C3-C10 heterocycloalkyl;
• each of L1 and L′1 is independently —O—, —C(Ra1Ra2)—, —C(O)—, —S—, —S(O)—, —S(O)2—, —N(Ra3)—, —N(Ra4)C(O)— or —N(Ra5)S(O)2—;
• wherein, each of Ra1, Ra2, Ra3, Ra4 and Ra5 is independently hydrogen or a C1-C6 alkyl;
• each of R1 and R′1 is independently —NR5R6;
• each of R5 and R6 is independently hydrogen or a C1-C10 alkyl;
• wherein the C1-C10 alkyl is substituted by one or more R7;
• when a plurality of R7 substituents are present, the substituents are the same or different;
• R7 is selected from the group consisting of hydrogen, hydroxyl, a halogen, a C3-C10 cycloalkyl and a C3-C10 heterocycloalkyl;
• alternatively, R5 and R6 together with the nitrogen atom to which they are attached form a substituted or unsubstituted heterocyclic ring;
• the substituted heterocyclic ring is substituted by one or more R8;
• when a plurality of R8 substituents are present, the substituents are the same or different;
• R8 is selected from the group consisting of a halogen, hydroxyl, a C1-C6 alkyl, a C3-C10 cycloalkyl, —C(O)ORb1, —C(O)Rb2, —NRb3Rb4, —C(O)NRb5, —OC(O)NRb6 or —NRb7C(O)NRb8;
• wherein, each of Rb1, Rb2, Rb3, Rb4, Rb5, Rb6, Rb7 and Rb8 is independently hydrogen or a C1-C6 alkyl;
• Z is C, N, O or S;
• Z′ is —O—, —S—, —N(R′4)— or —C(R′5R′6)—;
• each of R3, R′3, R′4, R′5 and R′6 is independently hydrogen, a C1-C10 alkyl or a C3-C10 cycloalkyl;
• wherein each of the C1-C10 alkyl and the C3-C10 cycloalkyl is independently substituted by one or more R9;
• when a plurality of R9 substituents are present, the substituents are the same or different;
• R9 is selected from the group consisting of hydrogen, a halogen, a C1-C6 alkyl, a C3-C10 cycloalkyl and a C3-C10 heterocycloalkyl;
• each of D and D′ is independently phenylene;
• each of R10 and R′10 is independently a halogen, nitro, cyano, hydroxyl, sulfhydryl, a C1-C6 alkyl, a C1-C6 alkoxy, a C3-C10 cycloalkyl, a C3-C10 heterocycloalkyl, —C(O)ORc1, —C(O)Rc2, —OC(O)Rc3, —NRc4Rc5, —NRc6C(O)Rc7, —C(O)NRc8, —OC(O)NRc9, —NRc10C(O)NRc11, —SRc12, —S(O)NRc13Rc14, —S(O)2NRc15Rc16, —NRc17S(O)2Rc18 or —NRc19S(O)Rc20;
• wherein each of Rc1, Rc2, Rc3, Rc4, Rc5, Rc6, Rc7, Rc8, Rc9, Rc10, Rc11, Rc12, Rc13, Rc14, Rc15, Rc16, Rc17, Rc18, Rc19 and Rc20 is independently hydrogen or a C1-C6 alkyl;
• each of m and m′ is independently 0, 1, 2, 3 or 4;
• when a plurality of R10 substituents are present on D, the substituents are the same or different;
• when a plurality of R′10 substitutions are present on D′, the substituents are the same or different;
• each of L2 and L′2 is independently a C1-C3 alkylene;
• each of L3 and L′3 is independently a C1-C6 alkylene or a C2-C6 heteroalkylene;
• each of the C1-C6 alkylene and the C2-C6 heteroalkylene is independently substituted by one or more R11;
• when a plurality of R11 substitutions are present, the substituents are the same or different;
• R11 is selected from the group consisting of hydrogen, a halogen, cyano, a C1-C6 alkyl, a C3-C10 cycloalkyl, a C3-C10 heterocycloalkyl, —ORd1, —SRd2, —NRd3Rd4;
• wherein each of Rd1, Rd2, Rd3 and Rd4 is independently hydrogen or a C1-C6 alkyl;
• each of R and R′ is independently hydrogen, a halogen, hydroxyl, a C1-C3 alkyl.