Compounds and pharmaceutical composition associated with ubiquitination-proteasome system

A method for providing therapeutic treatment to a neoplastic disease, an inflammatory disorder, an autoimmune disorder, a neurodegenerative disease or a metabolic disorder-comprising contacting a cell with an effective amount of the following compound or administering an effective amount of the following compound or a pharmaceutical composition comprising the following compound and a pharmaceutically acceptable carrier to a subject in need thereof;

• wherein the compound having the structure of:
• or a tautomer or stereoisomer thereof, or a solvate, prodrug or a pharmaceutically acceptable salt thereof.