Extracellular matrix metalloproteinase inducer (EMMPRIN) peptides and binding antibodies
AssigneesMor Research Applications Ltd., Technion Research & Development Foundation Limited
InventorsMichal A. Rahat, Nitza Lahat, Miriam Walter, Haim Bitterman
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Abstract
The invention provides isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within said peptides. Pharmaceutical compositions comprising said peptides and antibodies are also disclosed as well as methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.
Claims5
A method of treating cancer associated with expression of EMMPRIN comprising administering to a subject in need thereof a composition comprising at least one peptide of 11-25 amino acids, comprising a sequence selected from the group consisting of:
- GHRWMRGGKVLC (SEQ ID NO.:
- 1);
- and GHRWLKGGVVLC (SEQ ID NO.:
- 2), and a pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.