# US 11,079,455 B2 · Combined angiography and perfusion using radial imaging and arterial spin labeling > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,079,455 B2 - Document ID: US11079455B2 - Status: Granted - Kind: B2 - Application number: 15/731,113 - Filed: 2017-04-20 - Published: 2017-10-26 - Granted: 2021-08-03 - Earliest claimed: 2016-04-20 - Assignees: Oxford University Innovation Limited - Applicants: Oxford University Innovation Limited - Inventors: Thomas Okell - Web page: https://patentgrep.com/patent/US11079455B2 ## CPC - G01R 33/56366: {Perfusion imaging} - A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} - A61B 5/7425: {Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image} - A61B 5/489: {Blood vessels} - A61B 5/7285: {for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal} - A61B 2576/026: for the brain - G01R 33/4824: {using a non-Cartesian trajectory} - G16H 30/40: for processing medical images, e.g. editing - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract The present disclosure is directed to combined angiography and perfusion using radial imaging and arterial spin labeling. ## Claims ### Claim 1 A computer implemented method for combined angiography and perfusion imaging using radial imaging, comprising: labeling blood for dynamic imaging with arterial spin labeling and without use of a contrast agent; acquiring a data set from the labeled blood using radial imaging and a continuous readout scheme; reconstructing one or more angiography images from the data set, wherein the one or more reconstructed angiography images are reconstructed with a spatial and temporal resolution for angiography; and separately reconstructing one or more perfusion images from the data set, wherein the one or more reconstructed perfusion images are reconstructed with a spatial and temporal resolution for perfusion imaging, wherein the step of separately reconstructing one or more perfusion images includes separately reconstructing the one or more perfusion images from the same data set from which the one or more angiography images are reconstructed. ### Claim 2 (depends on 1) The method of claim 1, wherein the arterial spin labeling (ASL) is pseudo-continuous ASL, time-encoded ASL, pulsed ASL, or vessel-selective ASL. ### Claim 3 (depends on 1) The method of claim 1, wherein the radial imaging includes incrementing changing an azimuthal angle wherein the azimuthal angle is non-linearly incremented. ### Claim 4 (depends on 1) The method of claim 1, wherein the angiography temporal resolution is higher than the perfusion temporal resolution. ### Claim 5 (depends on 1) The method of claim 1, wherein the radial imaging includes taking full radial samples in a plane. ### Claim 6 (depends on 1) The method of claim 1, wherein the radial imaging includes acquiring non-cartesian radial samples within a sphere of k-space. ### Claim 7 (depends on 1) The method of claim 1, wherein the radial imaging is performed to allow reconstructing the one or more images at variable temporal resolution. ### Claim 8 (depends on 7) The method of claim 7, wherein the radial imaging is performed to allow reconstructing the one or more images at variable spatial resolution. ### Claim 9 (depends on 1) The method of claim 1, further comprising processing the one or more reconstructed angiography images with inflow subtraction. ### Claim 10 (depends on 1) The method of claim 1, further comprising processing the one or more reconstructed angiography images or the one or more reconstructed perfusion images with post-hoc spatial smoothing, or both. ### Claim 11 (depends on 1) The method of claim 1, wherein the acquired data set includes data from a readout module; the one or more angiography images are reconstructed from data from the readout module; and the one or more perfusion images are reconstructed from data from the readout module from which the one or more angiography images are also reconstructed. ### Claim 12 A system comprising: at least one computing device; at least one application executable in the at least one computing device, the at least one application comprising logic that: A. labels blood for dynamic imaging with arterial spin labeling and without use of a contrast agent; B. acquires a data set from the labeled blood set using radial imaging and a continuous readout scheme; C. reconstructs one or more angiography images from the data set, wherein the one or more reconstructed angiography images are reconstructed with a spatial and temporal resolution for angiography; and D. separately reconstructs one or more perfusion images from the data set, wherein the one or more reconstructed perfusion images are reconstructed with a spatial and temporal resolution for perfusion imaging, wherein the step of separately reconstructing one or more perfusion images includes separately reconstructing the one or more perfusion images from the same data set from which the one or more angiography images are reconstructed. ### Claim 13 (depends on 12) The system of claim 12, wherein arterial spin labeling (ASL) is pseudo-continuous ASL, time-encoded ASL, pulsed ASL, or vessel-selective ASL. ### Claim 14 (depends on 12) The system of claim 12, wherein the radial imaging includes incrementing an azimuthal angle wherein the azimuthal angle is non-linearly incremented. ### Claim 15 (depends on 12) The system of claim 12, wherein the angiography temporal resolution is higher than the perfusion temporal resolution. ### Claim 16 (depends on 12) The system of claim 12, wherein the radial imaging includes taking full radial samples in a plane. ### Claim 17 (depends on 12) The system of claim 12, wherein the radial imaging includes acquiring non-cartesian radial samples within a sphere of k-space. ### Claim 18 (depends on 12) The system of claim 12, wherein the radial imaging is performed to allow reconstructing the one or more images at variable temporal resolution. ### Claim 19 (depends on 18) The system of claim 18, wherein the radial imaging is performed to allow reconstructing the one or more images at variable spatial resolution. ### Claim 20 (depends on 12) The system of claim 12, wherein the logic further comprises logic that: E. processes the one or more reconstructed angiography images with inflow subtraction. ### Claim 21 (depends on 20) The system of claim 20, wherein the logic further comprises logic that: F. processes the reconstructed angiography images with post-hoc spatial smoothing. ### Claim 22 (depends on 21) The system of claim 21, wherein the logic further comprises logic that: G. processes the reconstructed perfusion images with post-hoc spatial smoothing. ### Claim 23 (depends on 12) The system of claim 12, wherein the radial imaging is a Golden Ratio radial readout scheme providing the continuous readout scheme to continuously image the labeled blood through large arteries and into the tissue of a subject. ### Claim 24 (depends on 12) The system of claim 12, wherein the acquired data set includes data from a readout module; the one or more angiography images are reconstructed from data from the readout module; and the one or more perfusion images are reconstructed from data from the readout module from which the one or more angiography images are also reconstructed. ### Claim 25 A computer implemented method for combined angiography and perfusion imaging using radial imaging, comprising: labeling blood for dynamic imaging with arterial spin labeling and without use of a contrast agent; acquiring a data set from the labeled blood using radial imaging and a continuous readout scheme; reconstructing one or more angiography images from the data set, wherein the one or more reconstructed angiography images are reconstructed with a spatial and temporal resolution for angiography; separately reconstructing one or more perfusion images from the data set, wherein the one or more reconstructed perfusion images are reconstructed with a spatial and temporal resolution for perfusion imaging; and wherein the radial imaging is a Golden Ratio radial readout scheme providing the continuous readout scheme to continuously image the labeled blood through large arteries and into the tissue of a subject.