# US 11,079,370 B2 · Measurement method and measurement device

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- Number: US 11,079,370 B2
- Document ID: US11079370B2
- Status: Granted
- Kind: B2
- Application number: 15/747,140
- Filed: 2016-05-31
- Published: 2018-08-02
- Granted: 2021-08-03
- Earliest claimed: 2015-07-30
- Assignees: KYOCERA Corporation
- Applicants: Kyocera Corporation
- Inventors: Kyosuke Kishimoto; Hideharu Kurioka; Atsuomi Fukuura
- Web page: https://patentgrep.com/patent/US11079370B2

## CPC

- G01N 33/5308: {for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites}
- G01N 27/4145: {specially adapted for biomolecules, e.g. gate electrode with immobilised receptors}
- G01N 29/022: {Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices (microdevices per se B81B)}
- G01N 29/4427: {with stored values, e.g. threshold values}
- G01N 33/53: Immunoassay; Biospecific binding assay; Materials therefor
- G01N 33/543: with an insoluble carrier for immobilising immunochemicals
- G01N 33/5438: {Electrodes}
- G01N 33/54388: {based on lateral flow}
- G01N 33/566: using specific carrier or receptor proteins as ligand binding reagents {where possible specific carrier or receptor proteins are classified with their target compounds}
- G01N 33/6893: {related to diseases not provided for elsewhere}
- G01N 33/723: {Glycosylated haemoglobin}
- G01N 21/553: {and using surface plasmons (fluorescence excitation G01N21/648; enhanced Raman G01N21/658)}
- G01N 2291/012: Phase angle
- G01N 2291/02466: Biological material, e.g. blood
- G01N 2291/02809: Concentration of a compound, e.g. measured by a surface mass change
- G01N 2333/4713: Plasma globulins, lactoglobulin
- G01N 2440/38: addition of carbohydrates, e.g. glycosylation, glycation
- G01N 2800/042: Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A measurement method includes a measurement step of measuring a first single value and a second signal value, the first signal value being based on a reaction between a first reacting substance and the sample, the second signal value being based on a reaction between a second reacting substance and the sample, the first reacting substance having a higher reactivity to a second detection target than to a first detection target, the second reacting substance having a higher reactivity to the first detection target than to the second detection target.

## Claims

### Claim 1

A measurement method, comprising:
preparing a first reacting substance and a second reacting substance, the first reacting substance having a higher reactivity to a second detection target than to a first detection target, the second reacting substance having a higher reactivity to the first detection target than to the second detection target, wherein the first detection target comprises a first disease-associated proteinaceous substance and the second detection target comprises a second disease-associated proteinaceous substance;
preparing a sample;
making the sample contact with the first reacting substance and the second reacting substance;
measuring a first signal value of a first reaction between the first reacting substance and the sample, and a second signal value of a second reaction between the second reacting substance and the sample; and
calculating a relationship between the first detection target and the second detection target in the sample based on a calibration curve which is prepared in advance, the first signal value, and the second signal value, wherein the calibration curve is prepared in advance based on a first reference signal value and a second reference signal value, the first reference signal value being based on a reaction between the first reacting substance and at least one reference sample having known concentrations of the first and second detection targets, and the second reference signal value being based on a reaction between the second reacting substance and the at least one reference sample.

### Claim 2 (depends on 1)

The measurement method according to claim 1, wherein the first reacting substance and the second reacting substance are each an antibody or an aptamer.

### Claim 3 (depends on 1)

The measurement method according to claim 1, wherein the first reacting substance and the second reacting substance are each an RNA aptamer.

### Claim 4 (depends on 1)

The measurement method according to claim 1, wherein
the first signal value and the second signal value are each a phase characteristic value.

### Claim 5 (depends on 1)

The measurement method according to claim 1, wherein the first signal value and the second signal value are each a value measured using a method selected from among QCM, SPR, and FET.

### Claim 6 (depends on 1)

The measurement method according to claim 1, wherein the sample is a blood sample.

### Claim 7 (depends on 1)

The measurement method according to claim 1, wherein the first detection target and the second detection target are each a proteinaceous substance.

### Claim 8 (depends on 7)

The measurement method according to claim 7, wherein the proteinaceous substance is a disease-associated proteinaceous substance.