# US 11,079,350 B2 · Solid state pH sensing continuous flow system

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- Number: US 11,079,350 B2
- Document ID: US11079350B2
- Status: Granted
- Kind: B2
- Application number: 15/469,234
- Filed: 2017-03-24
- Published: 2017-09-28
- Granted: 2021-08-03
- Earliest claimed: 2016-03-25
- Applicants: Parker-Hannifin Corporation
- Inventors: Thang Huy Vu; Steve Roth; Srinivas Rao
- Web page: https://patentgrep.com/patent/US11079350B2

## CPC

- G01N 27/302: {pH sensitive, e.g. quinhydron, antimony or hydrogen electrodes (ion selective electrodes G01N27/333, glass electrodes G01N27/36)}
- G01N 27/4167: {pH (electrodes therefor G01N27/302, G01N27/36)}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention relates generally to systems for measuring pH. In particular, the present invention relates to a continuous flow system having one or more solid state pH sensors positioned within a fluid pathway of the system to provide continuous pH measurement.

## Claims

### Claim 1

A continuous flow pH monitoring system, comprising:
a solid state pH sensor having an analyte sensitive material (ASM) covalently bound to a polymer backbone, wherein the ASM comprises at least one of a quinone, dihydroxy anthraquinone, or an anthraquinone derivative, and wherein the polymer backbone is poly(vinyl alcohol);
a pH sensor housing comprising:
an outer top surface comprising a threaded opening;
an outer bottom surface opposite the outer top surface;
a sidewall comprising an outer sidewall surface and an inner sidewall surface, said inner sidewall surface in fluid communication with the outer top surface via the threaded opening;
an inner bottom surface, said inner bottom surface and said inner sidewall surface defining a fluid pathway;
an inlet port positioned in the sidewall in proximity to, and spaced apart from, the inner bottom surface and in fluid communication with the fluid pathway; and
an outlet port positioned in the sidewall in proximity to the threaded opening and in fluid communication with the fluid pathway, such that a distance between the outlet port and the inner bottom surface is greater than a distance between the inlet port and the inner bottom surface;
a pH probe adapter threadedly coupled to the threaded opening of the pH sensor housing, the pH probe adapter further comprising a central opening configured to selectively receive the solid state pH sensor such that a distal tip of the ASM of the solid state pH sensor is positioned between the inner bottom surface and the inlet port;
a sealing member housed within the central opening of the pH probe adapter and interposed between the solid state pH sensor and the pH probe adapter to provide a fluid tight seal therebetween; and
a computer processor operably connected to the solid state pH sensor and configured to receive data from the solid state pH sensor.

### Claim 2 (depends on 1)

The system of claim 1, further comprising an upstream fluid source coupled to the inlet port.

### Claim 3 (depends on 2)

The system of claim 2, further comprising a fluid pump interposed between the upstream fluid source and the pH sensor housing.

### Claim 4 (depends on 2)

The system of claim 2, further comprising an in-line static mixer interposed between the upstream fluid source and the pH sensor housing.

### Claim 5 (depends on 1)

The system of claim 1, wherein the solid state pH sensor comprises a plurality of solid state electrodes.

### Claim 6 (depends on 5)

The system of claim 5, wherein the plurality of solid state electrodes are selected from the group consisting of a working electrode, a reference electrode, a pseudo reference electrode, and a counter electrode.

### Claim 7 (depends on 5)

The system of claim 5, wherein the inlet port and the outlet port define the fluid pathway through the pH sensor housing.

### Claim 8 (depends on 7)

The system of claim 7, wherein the fluid pathway maintains a constant flow of a fluid through the pH sensor housing.

### Claim 9 (depends on 7)

The system of claim 7, wherein the solid state pH sensor is positioned within the pH sensor housing such that the plurality of solid state electrodes is positioned in the fluid pathway in proximity to the inlet port.

### Claim 10 (depends on 1)

The system of claim 1, wherein the solid state pH sensor comprise a probe assembly having an elongated body, a portion of which is inserted through the central opening.

### Claim 11 (depends on 1)

The system of claim 1, wherein the solid state pH sensor further comprises an analyte insensitive material (AIM).

### Claim 12 (depends on 1)

The system of claim 1, wherein the solid state pH sensor measures pH accurately to within ±0.1 pH units.

### Claim 13 (depends on 12)

The system of claim 12, wherein the system supports flow rates from 5 ml/min to 500 ml/min.

### Claim 14 (depends on 1)

The system of claim 1, wherein the system provides real-time pH monitoring under flow conditions.