# US 11,079,339 B2 · Biosensor with integrated antenna and measurement method for biosensing applications > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,079,339 B2 - Document ID: US11079339B2 - Status: Granted - Kind: B2 - Application number: 15/997,874 - Filed: 2018-06-05 - Published: 2018-10-04 - Granted: 2021-08-03 - Earliest claimed: 2014-09-24 - Assignees: Bogazici Universitesi - Applicants: Bogazici Universitesi - Inventors: Hamdi Torun; Arda Deniz Yalcinkaya; Gunhan Dundar - Web page: https://patentgrep.com/patent/US11079339B2 ## CPC - G01N 22/00: Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more (G01N3/00 - G01N17/00, G01N24/00 take precedence) - H01Q 1/2208: {associated with components used in interrogation type services, i.e. in systems for information exchange between an interrogator/reader and a tag/transponder, e.g. in Radio Frequency Identification [RFID] systems (methods or arrangements for sensing record carriers, e.g. for reading patterns G06K7/00; record carrier for use with machines and with at least a part designed to carry digital markings G06K19/00)} - H01Q 1/225: {used in level-measurement devices, e.g. for level gauge measurement} - H01Q 9/0464: {Annular ring patch} - H01Q 9/40: Element having extended radiating surface - H01Q 15/006: {Selective devices having photonic band gap materials or materials of which the material properties are frequency dependent, e.g. perforated substrates, high-impedance surfaces} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - H01Q: ANTENNAS, i.e. RADIO AERIALS (radiators or antennas for microwave heating H05B6/72) ## Abstract The present invention relates to a biosensor (1) which enables the concentration of a desired molecule inside a liquid in the medium, and essentially comprises at least one metallic plate (2) which functions as a ground plate, and which is preferably manufactured from aluminum, at least one dielectric substrate (3) which is located on top of the metallic plate (2), at least one split-ring resonator (4) which is realized on top of the dielectric substrate (3), and which is coated with a dielectric layer, at least two symmetrical antennas (5) which are realized on the same plane with the split-ring resonator (4) on the substrate (3), at least two ports (6) where a network analyzer is connected with the antennas (5) via SMA (SubMiniature Version A) connectors. ## Claims ### Claim 1 A biosensor for measuring a concentration of a desired molecule inside a liquid medium, comprising: at least one metallic plate configured as a ground plate; at least one dielectric substrate located on top of the at least one metallic plate; at least one split-ring resonator realized on top of the at least one dielectric substrate, wherein the at least one split-ring resonator is a single split ring resonator coated with a dielectric layer; at least two symmetrical antennas realized on a same plane with the at least one split-ring resonator on top of the at least one dielectric substrate, wherein each of the at least two symmetrical antennas linearly and symmetrically extend from a respective first end to a respective second end in parallel to each other in said same plane on opposite sides and spaced away from the at least one split-ring resonator, wherein the respective first end of the at least two symmetrical antennas is positioned at a first peripheral edge of the metallic plate, and the respective second end of the at least two symmetrical antennas is proximate a second peripheral edge of the metallic plate, wherein the second peripheral edge of the metallic plate is opposite the first peripheral edge of the metallic plate such that electromagnetic waves emitted from the at least two symmetrical antennas are interacted with the metallic plate for receipt by the at least one split-ring resonator; and at least two ports electrically coupled with the respective first end of the at least two symmetrical antennas, wherein a network analyzer is connected to the at least two symmetrical antennas via the at least two ports. ### Claim 2 (depends on 1) The biosensor according to claim 1, wherein the at least two symmetrical antennas are monopole patch antennas. ### Claim 3 (depends on 1) The biosensor according to claim 1, wherein the network analyzer is connected to the at least two symmetrical antennas via SMA connectors. ### Claim 4 (depends on 1) The biosensor according to claim 1, wherein the at least one split-ring resonator and the at least two symmetrical antennas are metallic structures disposed in the same plane to form an inductive-capacitive resonator in response to excitation with a magnetic field perpendicular to said same plane at a resonant frequency known as magnetic resonance (fm). ### Claim 5 (depends on 1) The biosensor according to claim 1, wherein the dielectric layer coated on the at least one split-ring resonator comprises a parylene layer, and wherein the parylene layer is treated with oxygen plasma. ### Claim 6 (depends on 1) The biosensor according to claim 1, wherein the at least one dielectric substrate comprises from FR4 material. ### Claim 7 (depends on 1) The biosensor according to claim 1, wherein the at least one dielectric substrate comprises alumina material. ### Claim 8 (depends on 1) The biosensor according to claim 1, wherein the at least one dielectric substrate comprises mica material. ### Claim 9 (depends on 1) The biosensor according to claim 1, wherein the at least one metallic plate comprises aluminum. ### Claim 10 (depends on 1) The biosensor according to claim 1, wherein the at least one split-ring resonator is positioned on top of the at least one dielectric substrate to receive the electromagnetic waves at a resonant frequency fm that induces a circulating current in the at least one split-ring resonator, and wherein the resonant frequency fm is defined as: f m = 1 2 ⁢ π ⁢ C eff ⁢ L eff , C eff = C g + C s where Ceff is an effective capacitance, and Leff is an effective inductance; C g = ɛ eff ⁢ h ⁢ ⁢ ω g + ɛ eff ⁡ ( h + g + w ) , where h and w are respectively thickness and width of the at least one split-ring resonator, and g is a slit gap of the at least one split-ring resonator; where C s = 2 ⁢ ɛ eff ⁢ ( h + ω ) π ⁢ ln ⁡ ( 4 ⁢ r g ) , where εeff is an effective permittivity of media surrounding the at least one split-ring resonator, r is radius of each ring of the at least one split-ring resonator. ### Claim 11 (depends on 1) The biosensor according to claim 1, wherein the at least one split-ring resonator comprises a split metallic ring realized on top of the at least one dielectric substrate. ### Claim 12 (depends on 1) The biosensor according to claim 1, wherein the at least two symmetrical antennas are arranged as linear members extending parallel to the at least one metallic plate such that the electromagnetic waves propagate perpendicular to a normal of the split-ring resonator. ### Claim 13 (depends on 1) The biosensor according to claim 1, wherein the at least two ports are located on top of the metallic plate proximate the first peripheral edge of the metallic plate. ### Claim 14 (depends on 1) The biosensor according to claim 1, wherein the first respective end of at least two symmetrical antennas are positioned closer to the first peripheral edge of the metallic plate and the at least two ports than the at least one split-ring resonator. ### Claim 15 (depends on 14) The biosensor according to claim 14, wherein the second respective end of at least two symmetrical antennas are positioned closer to the second peripheral edge of the metallic plate than the at least one split-ring resonator.