Vaccines against Zika virus based on Zika structure proteins
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsQiang Chen, Haiyan Sun, Huafang Lai, Ming Yang
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Abstract
Compositions including a virus-like particle (VLP)-based vaccine displaying a portion of ZIKV envelope protein (E) domain III (DIII) and a portion of ZIKV envelope protein (E) and related methods are disclosed herein. Further, compositions including vaccines comprising a portion of ZIKA virus E protein, wherein the portion of ZIKA virus E protein is either a full-length version of ZIKA virus E protein or a functionally equivalent version of the full-length ZIKA virus E protein, are disclosed.
Claims11
An immunogenic composition comprising virus like particles (VLPs) comprising a fusion protein, wherein the fusion protein comprises (i) at least a portion of ZIKA virus envelope (E) protein domain III (zDIII) polypeptide and (ii) at least a portion of a Hepatitis B core Antigen (HBcAg) capable of forming a VLP.
Dependencies are inferred from the claim text.