Prophylaxis of thrombosis
AssigneeTranslational Sciences Inc.
InventorGuy L. Reed
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Abstract
The invention provides a method and composition for preventing thrombosis and complications associated therewith by targeting Sf2 directly. The invention provides Sf2-deficiency or prophylactic administration of a therapeutic agent, such as a Sf2 antagonist or a Sf2 antibody, markedly reduces thrombus formation that would otherwise be caused due to surgery, immobility, genetic abnormality, cancer, trauma, or other risk factors.
Claims10
A method for inhibiting thrombosis in a human individual in need comprising administering to the individual a thrombosis prophylactic amount of a composition comprising an anti-Serpin f2 (Sf2) antibody, or a functional fragment thereof, that inhibits Sf2-dependent thrombosis, and a pharmaceutically acceptable carrier, wherein prior to the administering step the subject has not been determined to have a thrombus.
Dependencies are inferred from the claim text.