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US 11,078,240 B2Granted
Covalently fused viral coat proteins for the display of target molecules
AssigneeFraunhofer USA, Inc.
InventorsStephen Tottey, Konstantin Musiychuk
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AssigneeFraunhofer USA, Inc.
InventorsStephen Tottey, Konstantin Musiychuk
Estimating the term…
A fusion protein comprising a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may form a virus like particle (VLP). Where the fusion protein further comprises a target protein, the target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.
A fusion protein comprising a target protein, a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide, wherein the target protein is at N-terminus of the first recombinant viral coat protein, wherein the first recombinant viral coat protein is linked to N-terminus of the first linkage peptide, wherein the second recombinant viral coat protein is linked to C-terminus of the first linkage peptide, wherein the first recombinant viral coat protein comprises an amino acid sequence at least 80% identical to SEQ ID NO:
Dependencies are inferred from the claim text.