Triplet-triplet annihilation upconversion system, and compositions and methods thereof for drug delivery
AssigneeUniversity of Massachusetts
InventorsGang Han, Ling Huang
Life of this patent
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Abstract
The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.
Claims17
An upconversion composition, comprising an organic triplet photosensitizer molecule and an organic emitter molecule, wherein the composition is characterized by an upconversion upon excitation in the red region of about 500 nm to about 600 nm or far red region of about 600 nm to about 700 nm with an emission in the deep blue region of about 410 nm to about 550 nm, wherein each of the triplet photosensitizer and emitter molecules comprises no metallic elements, wherein the triplet photosensitizer molecule has the structural formula (I):
- wherein
- each of R1 and R2 is independently selected from the group consisting of:
- H, bromo, iodio, alkynyl, alkyl, alkenyl, azide, PEG, amino, carboxyl acid and hydroxyl;
- R3 is selected from the group consisting of:
- bromo and iodio;
- R4 is an arylethynyl group;
- and
- each R5 is independently selected from the group consisting of:
- H and alkyl.
A compound having the structural formula (I):
- wherein
- each of R1 and R2 is independently selected from the group consisting of:
- H, bromo, iodio, alkynyl, alkyl, alkenyl, azide, PEG, amino, carboxyl acid and hydroxyl;
- R3 is selected from the group consisting of:
- bromo and iodio;
- R4 is an arylethynyl group;
- and
- each R5 is independently selected from the group consisting of:
- H and alkyl.
A biocompatible nanoparticle delivery system, comprising:
- a triplet photosensitizer molecule and an emitter molecule, wherein
- each of the triplet photosensitizer and emitter molecules is an organic molecule and comprises no metallic elements;
- the triplet photosensitizer is excited by a light in the red region of about 500 nm to about 600 nm or far red region of about 600 nm to about 700 nm causing an emission by the emitter molecule in the deep blue region of about 410 nm to about 550 nm;
- and
- a photolabile molecule comprising a biologically active agent, wherein the biologically active agent is releasable upon absorption of the emission by the emitter molecule, wherein the triplet photosensitizer molecule has the structural formula (I):
- wherein
- each of R1 and R2 is independently selected from the group consisting of:
- H, bromo, iodio, alkynyl, alkyl, alkenyl, azide, PEG, amino, carboxyl acid and hydroxyl;
- R3 is selected from the group consisting of:
- bromo and iodio;
- R4 is an arylethynyl group;
- and
- each R5 is independently selected from the group consisting of:
- H and alkyl.
Dependencies are inferred from the claim text.