# US 11,078,193 B2 · Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

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- Number: US 11,078,193 B2
- Document ID: US11078193B2
- Status: Granted
- Kind: B2
- Application number: 15/117,146
- Filed: 2015-02-05
- Published: 2016-12-01
- Granted: 2021-08-03
- Earliest claimed: 2014-02-06
- Assignees: Janssen Sciences Ireland UC
- Applicants: Janssen Sciences Ireland UC
- Inventors: Koen Vandyck; Geerwin Yvonne Paul Haché; Stefaan Julien Last; Geert Rombouts; Wim Gaston Verschueren; Pierre Jean-Marie Bernard Raboisson
- Web page: https://patentgrep.com/patent/US11078193B2

## CPC

- C07D 405/14: containing three or more hetero rings
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61K 31/4545: containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/12: Antivirals
- A61P 31/20: for DNA viruses
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

## Claims

### Claim 1

A compound of Formula (A)
or a stereoisomer or tautomeric form thereof, wherein:
is
is a 6 membered heteroaryl containing one nitrogen atom;
X is CR7;
Y is CR8;
Ra, Rb, Rc and Rd are independently selected from the group consisting of hydrogen, fluoro, bromo, chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C3-C4cycloalkyl and —C1-C4alkyl;
R4 is hydrogen, —C1-C3alkyl or C3-C4cycloalkyl;
R5 is hydrogen;
R6 is selected from the group consisting of C2-C6alkyl, and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, wherein said 3-7 membered saturated ring and said C2-C6alkyl are optionally substituted with one or more substituents each independently selected from the group consisting of hydrogen, —OH, fluoro, oxo, and C1-C4alkyl wherein said C1-C4alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro and —OH; and
R7 and R8 are each independently selected from the group consisting of hydrogen, methyl, —CN, fluoro, bromo and chloro;
or a pharmaceutically acceptable salt or a solvate thereof.

### Claim 2 (depends on 1)

A compound according to claim 1 with Formula (ID)
or a stereoisomer or tautomeric form thereof, wherein:
is
X is CR7;
Y is CR8;
Ra is selected from the group consisting of fluoro, bromo, chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C3-C4cycloalkyl and —C1-C4alkyl;
Rb and Rc are each independently hydrogen or fluoro;
R4 is hydrogen, —C1-C3alkyl or C3-C4cycloalkyl;
R5 is hydrogen;
R6 is selected from the group consisting of C2-C6alkyl, a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of hydrogen, —OH, fluoro, oxo, and C1-C4alkyl optionally substituted with one or more fluoro and/or —OH; and
R7 and R8 are each independently hydrogen, methyl, —CN, fluoro or chloro;
or a pharmaceutically acceptable salt or a solvate thereof.

### Claim 3 (depends on 1)

A compound according to claim 1 wherein R4 is methyl.

### Claim 4 (depends on 1)

A compound according to claim 1 wherein R6 contains a 3-7 membered saturated ring optionally containing one oxygen.

### Claim 5 (depends on 1)

A compound according to claim 1 wherein R6 is a 4 membered saturated ring containing one oxygen, and wherein said 4 membered saturated ring is optionally substituted with one or more C1-C4alkyl.

### Claim 6 (depends on 1)

A compound according to claim 1 wherein R6 is a branched C3-C6alkyl optionally substituted with one or more fluoro, or wherein R6 is a C3-C6cycloalkyl wherein said C3-C6cycloalkyl is substituted with one or more fluoro or substituted with C1-C4 substituted with one or more fluoro.

### Claim 7 (depends on 6)

A compound according to claim 6 wherein R6 is a branched C3-C6alkyl substituted with one or more fluoro.

### Claim 8 (depends on 1)

A compound according to claim 1 wherein R8 is fluoro or chloro.

### Claim 9 (depends on 1)

A compound according to claim 1 wherein Rb and Rc are each hydrogen.

### Claim 10 (depends on 1)

A method of treating an HBV infection comprising administering a therapeutically effective amount of at least one compound according to claim 1.

### Claim 11 (depends on 1)

A pharmaceutical composition comprising a compound according to claim 1, and a pharmaceutically acceptable carrier.

### Claim 12 (depends on 1)

A product containing (a) a compound according to claim 1, and (b) at least one HBV inhibitor, as a combined preparation for simultaneous, separate or sequential use in the treatment of HBV infections.

### Claim 13 (depends on 1)

A compound according to claim 1, wherein
R4 is methyl;
R6 is a branched C3-C6alkyl optionally substituted with one or more fluoro, or R6 is a C3-C6cycloalkyl optionally substituted with one or more fluoro or substituted with C1-C4 optionally substituted with one or more fluoro;
R8 is fluoro or chloro; and
Ra, Rb, Rc and Rd are each independently selected from the group consisting of hydrogen, fluoro, bromo, chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C3-C4cycloalkyl and —C1-C4alkyl.

### Claim 14 (depends on 2)

A compound according to claim 2, wherein R4 is methyl.

### Claim 15 (depends on 2)

A compound according to claim 2, wherein R6 contains a 3-7 membered saturated ring optionally containing one oxygen.

### Claim 16 (depends on 2)

A compound according to claim 2, wherein R8 is fluoro or chloro.

### Claim 17 (depends on 1)

A compound according to claim 1 selected from the group consisting of:
N-(2-cyanopyridin-4-yl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide;
1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[5-(trifluoromethyl)pyridin-3-yl]-1H-pyrrole-2-carboxamide;
N-(6-fluoro-5-methylpyridin-3-yl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide;
1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[4-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide;
1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[6-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide;
4-(tert-butylsulfamoyl)-3-chloro-N-(2-cyanopyridin-4-yl)-1-methyl-1H-pyrrole-2-carboxamide;
3-chloro-N-(5-fluoro-6-methylpyridin-2-yl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
3-chloro-1-methyl-N-(2-methylpyridin-4-yl)-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
3-chloro-N-(2-cyanopyridin-4-yl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
3-chloro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-N-[2-(trifluoromethyl)pyridin-4-yl]-1H-pyrrole-2-carboxamide;
3-chloro-N-(2-fluoropyridin-4-yl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
3-chloro-N-(2-chloropyridin-4-yl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
3-chloro-N-(6-fluoro-5-methylpyridin-3-yl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
3-chloro-N-(3-fluoro-2-methyl-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-1-methyl-N-(2-pyridyl)-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-1-methyl-N-(4-pyridyl)-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-1-methyl-N-(3-pyridyl)-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-Cyanopyridin-4-yl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
N-(2-Cyanopyridin-4-yl)-3-fluoro-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
3-chloro-N-(6-cyano-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-N-(2-fluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(6-cyano-2-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-[6-(trifluoromethyl)-2-pyridyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide;
3-fluoro-N-(5-fluoro-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(5-bromo-6-fluoro-3-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-3-fluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(5-bromo-6-fluoro-3-pyridyl)-3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2,6-difluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-6-methyl-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-1-methyl-4-[[(1R)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-(2,3,6-trifluoro-4-pyridyl)pyrrole-2-carboxamide;
3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-(2,3,5-trifluoro-4-pyridyl)pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-1-methyl-4[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(6-fluoro-3-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(5-fluoro-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
3-chloro-N-[3-fluoro-2-(trifluoromethyl)-4-pyridyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(5,6-difluoro-3-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(6-chloro-5-fluoro-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(6-bromo-5-fluoro-2-pyridyl)-3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2,6-difluoro-3-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-4-(isopropylsulfamoyl)-1-methyl-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-3-fluoro-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide;
4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-4-[[(1R)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[(1R)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
(+/−)-3-chloro-N-(2-chloro-4-pyridyl)-4-[(2-hydroxy-1-methyl-propyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-4-[[3-(hydroxymethyl)oxetan-3-yl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-4-[(3-hydroxycyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-(2-fluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-N-(2-fluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-(2-fluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-(2,6-difluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-3-fluoro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-4-pyridyl]-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2,6-difluoro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-chloro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-fluoro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-3-fluoro-4-pyridyl)-1-methyl-4-[[(1R)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-chloro-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-3-fluoro-4-pyridyl)-4-[(3, 3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-N-(2,6-difluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-N-(2-fluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-6-cyano-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-3-fluoro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2,6-dichloro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
4-[(2,2-difluorocyclobutyl)sulfamoyl]-N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-4-[[1-(fluoromethyl)cyclobutyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
N-[2-(1,1-difluoroethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-6-methyl-4-pyridyl)-4-[(3, 3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-N-(2-fluoro-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
N-(2,6-dibromo-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2,6-dichloro-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2,3-difluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2,5-difluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-6-methyl-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-3-fluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2,6-dimethyl-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-[2-(fluoromethyl)-4-pyridyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(6-cyano-5-fluoro-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-6-methyl-4-pyridyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-6-methyl-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-N-[2-(trifluoromethyl)-4-pyridyl]pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-3-fluoro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-fluoro-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-6-methyl-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-N-(5-fluoro-6-methyl-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-6-methyl-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-6-methyl-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-pyrrole-2-carboxamide;
4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-3-chloro-4-[(3, 3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-N-(2-cyano-3-fluoro-4-pyridyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide;
3-chloro-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-6-methyl-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-N-(2-fluoro-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2, 3-difluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-6-methyl-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
3-fluoro-N-(2-fluoro-6-methyl-4-pyridyl)-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-6-methyl-4-pyridyl]-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-4-[(2,2-difluorocyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-6-methyl-4-pyridyl]-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-6-methyl-4-pyridyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(2-chloro-4-pyridyl)-1-methyl-4-[[4-(trifluoromethyl)tetrahydropyran-4-yl]sulfamoyl]pyrrole-2-carboxamide;
3-cyano-N-(6-cyano-5-fluoro-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-[2-(1,1-difluoroethyl)-4-pyridyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(4-cyano-2-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-(3,5,6-trifluoro-2-pyridyl)pyrrole-2-carboxamide;
3-chloro-N-(3-chloro-2,6-difluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(3,5-dichloro-2,6-difluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
3-chloro-N-(3-chloro-2,5,6-trifluoro-4-pyridyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-3-fluoro-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]pyrrole-2-carboxamide;
N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-fluoro-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-cyano-3-fluoro-4-pyridyl)-4-[(3, 3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[3-(trifluoromethyl)oxetan-3-yl]sulfamoyl]pyrrole-2-carboxamide;
N-(2,6-difluoro-4-pyridyl)-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-4-pyridyl)-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-3-fluoro-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-3-fluoro-4-pyridyl]-3-fluoro-1-methyl-4-[[3-(trifluoromethyl)oxetan-3-yl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-4-pyridyl)-3-fluoro-1-methyl-4-[[3-(trifluoromethyl)oxetan-3-yl]sulfamoyl]pyrrole-2-carboxamide;
N-[2-(difluoromethyl)-4-pyridyl]-3-fluoro-1-methyl-4-[[3-(trifluoromethyl)oxetan-3-yl]sulfamoyl]pyrrole-2-carboxamide;
N-(2,6-difluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[3-(trifluoromethyl)oxetan-3-yl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-3-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[3-(trifluoromethyl)oxetan-3-yl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-6-methyl-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-chloro-6-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide;
N-(2-bromo-6-fluoro-4-pyridyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; and
N-(2-chloro-4-pyridyl)-3-fluoro-1-methyl-4-[[1-(2,2,2-trifluoroethyl)-4-piperidyl]sulfamoyl]pyrrole-2-carboxamide; and
pharmaceutically acceptable salts thereof.

### Claim 18 (depends on 17)

A pharmaceutical composition comprising a compound according to claim 17, and a pharmaceutically acceptable carrier.

### Claim 19 (depends on 17)

A method of treating an HBV infection comprising administering a therapeutically effective amount of at least one compound of claim 17.

### Claim 20 (depends on 17)

A product containing (a) a compound according to claim 17, and (b) at least one HBV inhibitor, as a combined preparation for simultaneous, separate or sequential use in the treatment of HBV infections.