Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof

An aromatic acetylene or aromatic ethylene compound represented by formula II-0, a pharmaceutically acceptable salt, a tautomer, a mesomer, a racemate or a stereoisomer thereof:

• wherein, ring A and ring B are independently an aromatic ring or a heteroaromatic ring;
• L is alkynyl, —C(R4)═C(R5)— or C2-C10 heteroaryl having at least one N;
• when L is C2-C10 heteroaryl, the N atom thereof links to the ring A, and the C atom thereof links to the ring C;
• X1 is N or —CR6;
• X2 is N or —CR7;
• X3 is N or —CR8;
• X1, X2 and X3 are not N simultaneously;
• each of R1 is independently hydrogen, deuterium, substituted or unsubstituted hydroxy, substituted or unsubstituted amino, halogen, substituted or unsubstituted alkyl or substituted or unsubstituted alkoxy;
• each of R2 is independently hydrogen, deuterium, substituted or unsubstituted hydroxy, substituted or unsubstituted amino, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy,
• wherein R1a is C1-C4 alkyl;
• or two adjacent R2 together with the two atoms on the ring B to which they are attached form a 5-7 membered substituted or unsubstituted carbocycle, or substituted or unsubstituted heterocycle;
• in the heterocycle, the heteroatom is oxygen and/or nitrogen, the number of the heteroatom(s) is 1-4;
• R3 is deuterium, halogen, cyano, or substituted or unsubstituted alkyl;
• R4 and R5 are each independently hydrogen, deuterium, substituted or unsubstituted alkyl, or, substituted or unsubstituted cycloalkyl, or R4 and R5 together with the carbon-carbon double bond to which they are attached form a 5-7 membered substituted or unsubstituted carbocycle, or substituted or unsubstituted heterocycle;
• in the heterocycle, the heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur, the number of the heteroatom(s) is 1-4;
• R6, R7 and R8 are each independently hydrogen, deuterium, substituted or unsubstituted hydroxy, halogen, substituted or unsubstituted amino, substituted or unsubstituted alkyl, or, substituted or unsubstituted alkoxy, or R6 and R7 together with the two atoms on the ring C to which they are attached form a 5-7 membered substituted or unsubstituted heterocycle;
• or R7 and R8 together with the two atoms on the ring C to which they are attached form a 5-7 membered substituted or unsubstituted heterocycle;
• in the heterocycle, the heteroatom is nitrogen and/or oxygen, the number of the heteroatom(s) is 1-4;
• m1 is 0, 1 or 2;
• n is 1 or 2;
• in the definition of each R1, the substituent in the substituted alkyl or the substituted alkoxy is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• benzyl, benzyl substituted by cyano, C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• the substituent in the substituted hydroxy or the substituted amino is selected from the group consisting of C1-C4 alkyl, benzyl, benzyl substituted by cyano, C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• in the definition of each R2, the substituent in the substituted alkyl or the substituted alkoxy is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• the substituent in the substituted hydroxy or the substituted amino is selected from the group consisting of C1-C4 alkyl, benzyl, benzyl substituted by cyano, C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when two adjacent R2 together with the two atoms on the ring B to which they are attached form a 5-7 membered substituted carbocycle or substituted heterocycle, the substituent in the substituted carbocycle or in the substituted heterocycle is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when there are more substituents than one, the substituents are the same or different;
• in the definition of R4 or R5, the substituent in the substituted alkyl or the substituted cycloalkyl is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy, amino, C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when R4 and R5 together with the carbon-carbon double bond to which they are attached form a 5-7 membered substituted carbocycle, or, substituted heterocycle, the substituent in the substituted carbocycle or the substituted heterocycle is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when there are more substituents than one, the substituents are the same or different;
• in the definition of R6, R7 or R8, the substituent in the substituted alkyl or the substituted alkoxy is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• the substituent in the substituted hydroxy or the substituted amino is selected from the group consisting of C1-C4 alkyl, benzyl, benzyl substituted by cyano, C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when R6 and R7 together with the two atoms on the ring C to which they are attached form a 5-7 membered substituted heterocycle, or when R7 and R8 together with the two atoms on the ring C to which they are attached form a 5-7 membered substituted heterocycle, the substituent in the substituted heterocycle is selected from the group consisting of halogen, C1-4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when there are more substituents than one, the substituents are the same or different;
• in
• R11 and R12 are independently hydrogen, substituted or unsubstituted alkyl, alkoxy, hydroxyalkyl, aminoalkyl, substituted or unsubstituted C6-C14 aryl or substituted or unsubstituted C3-C6 cycloalkyl;
• or R11 and R12 together with the nitrogen atom to which they are attached form a 5-7 membered substituted or unsubstituted heterocycle;
• in the heterocycle, the heteroatom is nitrogen, or nitrogen and oxygen, the number of the heteroatom(s) is 1-4;
• in the definition of R11 or R12, the substituent in the substituted alkyl, the substituted C6-C14 aryl or the substituted C3-C6 cycloalkyl is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when R11 and R12 together with the nitrogen atom to which they are attached form a 5-7 membered substituted or unsubstituted heterocycle, the substituent in the substituted heterocycle is selected from the group consisting of halogen, C1-C4 alkyl, substituted C1-C4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• the substituent in the substituted C1-C4 alkyl is selected from the group consisting of halogen, C1-C4 alkyl, hydroxy,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group or C1-C4 acylamino;
• when there are more substituents than one, the substituents are the same or different;
• in
• Ra1 and Rb1 are independently hydrogen, C1-C4 alkyl or
• Ra11 is C1-C4 alkyl.