# US 11,078,177 B2 · Compounds for optically active devices

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- Number: US 11,078,177 B2
- Document ID: US11078177B2
- Status: Granted
- Kind: B2
- Application number: 16/560,265
- Filed: 2019-09-04
- Published: 2019-12-26
- Granted: 2021-08-03
- Earliest claimed: 2015-08-21
- Assignees: Merck Patent GmbH
- Applicants: Merck Patent GmbH
- Inventors: Lars Dobelmann-Mara; Stefan Riedmueller; Martin Schraub
- Web page: https://patentgrep.com/patent/US11078177B2

## CPC

- C07D 311/16: substituted in position 7
- A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- C07D 335/06: Benzothiopyrans; Hydrogenated benzothiopyrans
- C08F 20/30: containing aromatic rings in the alcohol moiety
- C08F 20/38: Esters containing sulfur
- C08F 20/40: Esters of unsaturated alcohols {, e.g. allyl (meth)acrylate}
- G02B 1/041: {Lenses}
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS

## Abstract

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds.

## Claims

### Claim 1

An optically active intraocular lens article which comprises, a copolymer comprising: one or more polymer units M1 selected from units of the following formulae (P-1) to (P-63); and one or more different polymer units:
wherein,
each * in the formulae indicates a linkage to an adjacent unit of the copolymer, and
n indicates the number of units of the formula.

### Claim 2 (depends on 1)

The intraocular lens article according to claim 1, wherein the one or more different polymer units in the copolymer comprise at least one unit M2, which at each occurrence is independently selected from the group consisting of a polymerized unit derived from ethylene, propylene, an acrylate, a methacrylate and a styrene.

### Claim 3 (depends on 2)

The intraocular lens article according to claim 2, wherein the copolymer comprises units M1 and M2 in a ratio m1:m2 of from 0.01 to 100.

### Claim 4 (depends on 1)

The intraocular lens article according to claim 1, wherein intraocular lens article further comprises a UV absorber.

### Claim 5 (depends on 1)

A process of forming the intraocular lens article of claim 1, said process comprising:
a) providing a composition comprising the copolymer; and
b) subsequently forming the intraocular lens article from said composition.

### Claim 6 (depends on 1)

A process of changing the optical properties of an intraocular lens article of claim 1, said process comprising:
a) providing the intraocular lens article, and
b) subsequently exposing said article to irradiation having a wavelength of at least 200 nm and at most 1500 nm, whereby at least one optical property of the article is changed.

### Claim 7 (depends on 6)

An intraocular lens article produced by the process according to claim 6.

### Claim 8 (depends on 1)

The intraocular lens article according to claim 1, wherein one or more polymer units M1 and/or one or more different polymer units in the copolymer are crosslinked with each other.

### Claim 9 (depends on 1)

The intraocular lens article according to claim 1, wherein the lens article further comprises one or more optic components and one or more haptic components, wherein the one or more optic components serve as a lens and the one or more haptic components are attached to the one or more optic components and hold the one or more optic components in place in the eye.

### Claim 10 (depends on 9)

The intraocular lens article according to claim 9, wherein the lens article has a one-piece design wherein the one or more optic components and the one or more haptic components are formed from a single piece of material.

### Claim 11 (depends on 9)

The intraocular lens article according to claim 9, wherein the lens article has a multi-piece design wherein the one or more optic components and the one or more haptic components are formed separately and then combined.

### Claim 12 (depends on 1)

A process of forming the intraocular lens article of claim 1, said process comprising:
a) polymerizing a compound according to formulae (M-1) to (M-63) together with precursor materials to produce the copolymer having one or more polymer units M1 and the one or more different polymer units
b) subsequently forming the intraocular lens article from said composition.