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US 11,078,167 B2Granted
Process for the preparation of Deferasirox
AssigneeAurobindo Pharma Ltd
InventorsHero Velladurai, Janardhana Rao Vascuri, Ravi Shankar Sathu, Sivakumaran Meenakshisunderam
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Abstract
The present invention provides an improved process for the preparation of Deferasirox of Formula-I substantially free from ‘hydrazino impurity’ by the condensation of 2-(2-hydrophenyl)-4H-1,3-benzoxazin-4-one of Formula-IV with 4-hydrazino benzoic acid of Formula-V in a polar solvent.
Claims2
A process for the preparation of Deferasirox of Formula (I):
- which comprises:
- (i) reacting 2-(2-hydrophenyl)-4H-1,3-benzoxazin-4-one of Formula-IV with 4-hydrazinobenzoic acid of Formula-V in a polar solvent selected from the group comprising tetrahydrofuran, N,N-dimethyl formamide, Dimethyl sulfoxide, acetonitrile, or mixtures thereof to obtain Deferasirox of Formula-I
- (ii) isolating Deferasirox of Formula-I.
Dependencies are inferred from the claim text.