# US 11,078,166 B2 · Triazole conjugated ureas, thioureas, carbamates, and reversed carbamates for PSMA-targeted imaging agents and uses thereof

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- Number: US 11,078,166 B2
- Document ID: US11078166B2
- Status: Granted
- Kind: B2
- Application number: 15/752,340
- Filed: 2016-08-15
- Published: 2019-07-25
- Granted: 2021-08-03
- Earliest claimed: 2015-08-13
- Assignees: The Johns Hopkins University
- Applicants: The Johns Hopkins University
- Inventors: Martin G. Pomper; Ying Chen; Xing Yang; Ronnie C. Mease; Sangeeta Ray
- Web page: https://patentgrep.com/patent/US11078166B2

## CPC

- C07D 249/04: 1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- A61K 51/0402: {carboxylic acid carriers, fatty acids (amino acids A61K51/0406)}
- A61K 51/0453: {having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole}
- C07B 59/002: {Heterocyclic compounds}
- A61K 2123/00: Preparations for testing in vivo
- C07B 2200/05: Isotopically modified compounds, e.g. labelled
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.

## Claims

### Claim 1

A compound having the following structure: