Method for resolution of baclofen salts
AssigneeUniversite De Rouen
InventorsGérard Coquerel, Julien Mahieux, François-Xavier Gendron
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Abstract
The invention relates to the field of resolution of chiral compounds existing in the form of two optical antipodes (enantiomers), such as Baclofen. More particularly, the invention relates to the production of the pure enantiomer (R)(−) Baclofen, of chemical nomenclature (R)-4-amino-3-(4-chlorophenyl)-butanoic acid, and the hydrogen maleate salt thereof. More specifically, the invention relates to the resolution of hydrogen maleate salts of racemic Baclofen by preferential crystallisation and particularly by the AS3PC method (auto-seeded and programmed polythermal preferential crystallisation).
Claims14
A racemic salt of baclofen hydrogen maleate (Bahma), wherein said racemic salt of baclofen hydrogen maleate has a melting/decomposition point of 164±1° C.
A process for the enantiomeric purification of baclofen hydrogen maleate (Bahma) salts, comprising the recrystallization of the Bahma salts in a solvent.
Dependencies are inferred from the claim text.