# US 11,077,263 B2 · Disposable ampoule for an aerosol generating device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,077,263 B2 - Document ID: US11077263B2 - Status: Granted - Kind: B2 - Application number: 14/992,156 - Filed: 2016-01-11 - Published: 2016-07-14 - Granted: 2021-08-03 - Earliest claimed: 2007-11-23 - Assignees: PARI Pharma GmbH - Applicants: PARI Pharma GmbH - Inventors: Mihaela Loenner; Thomas Gallem; Uwe Hetzer - Web page: https://patentgrep.com/patent/US11077263B2 ## CPC - A61M 15/0031: {by bursting or breaking the package, i.e. without cutting or piercing} - A61J 1/067: {Flexible ampoules, the contents of which are expelled by squeezing} - A61M 11/00: Sprayers or atomisers specially adapted for therapeutic purposes (in general B05B; {aerosol containers B65D83/14}) - A61M 11/005: {using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06)} - A61M 15/0028: {using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up} - A61M 15/0036: {hollow piercing means} - A61M 15/004: {with fixed piercing or cutting means} - A61M 15/009: {using medicine packages with incorporated spraying means, e.g. aerosol cans (pocket atomiser of the injector type A61M11/08)} - B65D 1/0238: {Integral frangible closures} - B65D 1/095: {made of flexible material} - A61M 15/0085: {using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06)} - A61M 2202/0468: non-physiological - A61M 2205/6054: Magnetic identification systems - A61M 2205/6072: Bar codes - A61M 2207/00: Methods of manufacture, assembly or production - A61M 2210/0618: Nose - A61M 2210/1039: Lungs - B05B 17/0646: {Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE - B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES - B05B: SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES (spray-mixers with nozzles B01F25/72; processes for applying liquids or other fluent materials to surfaces by spraying B05D) ## Abstract Disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body and a container bottom, and a predetermined break point that at least partly surrounds the container bottom, characterised by a collar that surrounds the predetermined break point at its outside and extends the container body over and beyond the container bottom. ## Claims ### Claim 1 A disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body and a container bottom extending in a plane perpendicular to a longitudinal direction of the ampoule, a predetermined break point that at least partly surrounds the container bottom, and a fixing groove formed in the container body, the fixing groove being provided centrally or closer to the container bottom in the longitudinal direction of the ampoule to absorb forces required to open the ampoule in the aerosol generating device and which arise when breaking the predetermined break point, wherein the ampoule at least at its inner contour tapers inwardly toward the container bottom in a first functional area of the container body and containing the container bottom, and a second functional area of the container body is substantially configured as a hollow cylinder, wherein the fixing groove includes an annular indentation into the container body and first and second portions of the container body located on opposite sides of the annular indentation, the first and second portions being raised with respect to a bottom part of the annular indentation and defining the annular indentation between them wherein the fixing groove is located between the first functional area and the second functional area, wherein at least one reinforcing rib is provided on the container body and wherein the reinforcing rib extends over a partial area of the container body, over and beyond the container bottom and over at least a partial area of a collar that surrounds the predetermined break point at its outside and extends the container body over and beyond the container bottom, an open end of the collar being spaced from the container body. ### Claim 2 (depends on 1) The ampoule according to claim 1, wherein the fixing groove extends in an annular manner around the container body. ### Claim 3 (depends on 1) The ampoule according to claim 1, wherein the reinforcing rib is provided on a side of the container bottom relative to the fixing groove. ### Claim 4 (depends on 1) The ampoule according to claim 1, wherein two diametrically opposed reinforcing ribs are provided. ### Claim 5 (depends on 1) The ampoule according to claim 1, wherein starting from the container bottom, the collar expands in a conical manner at least at its inner contour. ### Claim 6 (depends on 1) The ampoule according to claim 1, wherein the fixing groove is configured to mount the ampoule in the aerosol generating device and to retain the ampoule in a longitudinal direction of the ampoule. ### Claim 7 (depends on 6) The ampoule according to claim 6, wherein the fixing groove is configured to engage with catches of a translationally moveable element of the aerosol generating device. ### Claim 8 (depends on 7) The ampoule according to claim 7, wherein the fixing groove retains the ampoule in the translationally moveable element of the aerosol generating device, whereby the container bottom is pierced by a translational movement of the translationally moveable element and the retained ampoule relative to a hollow piercing element to open the ampoule and supply the medicament to the aerosol generating device. ### Claim 9 (depends on 1) The ampoule according to claim 1, wherein all parts of the ampoule are integrally formed. ### Claim 10 (depends on 9) The ampoule according to claim 9, which is produced by a blow-fill-seal process. ### Claim 11 (depends on 9) The ampoule according to claim 9, which is made of polyethylene, polypropylene or a thermoplastic copolymer. ### Claim 12 (depends on 1) The ampoule according to claim 1, wherein the medicament contains at least one active agent. ### Claim 13 (depends on 12) The ampoule according to claim 12, wherein the medicament contains at least one auxiliary agent in dissolved or suspended form. ### Claim 14 (depends on 1) The use of an ampoule according to claim 1 in an aerosol generating device, the medicament thereof being nebulized by an aerosol generator and being used for a local, nasal or pulmonary application. ### Claim 15 (depends on 1) The ampoule according to claim 1, wherein the predetermined break point at least partly surrounds the container bottom in the plane of the container bottom.