# US 11,077,255 B2 · Automatic injector devices and systems for controlled delivery of dosage and associated methods

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- Number: US 11,077,255 B2
- Document ID: US11077255B2
- Status: Granted
- Kind: B2
- Application number: 16/084,050
- Filed: 2017-03-13
- Published: 2020-09-24
- Granted: 2021-08-03
- Earliest claimed: 2016-03-11
- Assignees: QuiO Technologies LLC
- Applicants: QuiO Technologies LLC
- Inventors: Alexander Dahmani; Jared Schwartzentruber
- Web page: https://patentgrep.com/patent/US11077255B2

## CPC

- A61M 5/3157: {Means providing feedback signals when administration is completed (A61M5/20 takes precedence)}
- A61M 5/14: Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M 5/14248: {of the skin patch type}
- A61M 5/14566: {with a replaceable reservoir for receiving a piston rod of the pump}
- A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence)
- A61M 5/24: Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
- A61M 5/008: {Racks for supporting syringes or needles}
- A61M 2005/31588: {electrically driven}
- A61M 2005/3267: {Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body}
- A61M 2205/3368: Temperature
- A61M 2205/3592: using telemetric means, e.g. radio or optical transmission
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- A61M 2205/505: Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- A61M 2205/6054: Magnetic identification systems
- A61M 2205/8206: battery-operated
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Auto-injectors and associated assemblies and methods for delivery of liquid medicament in a controlled manner are disclosed herein.

## Claims

### Claim 1

A method for automated delivery of a liquid medicament to a subject from an injector assembly, the method comprising:
positioning a cartridge carrying the liquid medicament in an internal cavity of an injector;
receiving input to define one or more injection parameters;
calculating an injection force; and
initiating an injection of the liquid medicament using the injection force,
wherein calculating the injection force comprises calculating a viscosity of the liquid medicament using at least a rheology program stored in a memory of the injector assembly, and wherein the rheology program is specific to the liquid medicament.

### Claim 2 (depends on 1)

The method of claim 1, wherein receiving input comprises obtaining an injection speed for delivery of the liquid medicament from the cartridge to the subject.

### Claim 3 (depends on 1)

The method of claim 1, wherein receiving input comprises detecting a temperature of the liquid medicament.

### Claim 4 (depends on 1)

The method of claim 1, wherein receiving input comprises detecting identification information on a RFID tag on the cartridge.

### Claim 5 (depends on 1)

The method of claim 1, wherein initiating the injection of the liquid medication using the injection force includes delivering the liquid medicament within a pre-selected delivery time.

### Claim 6 (depends on 1)

The method of claim 1, further comprising sending a notification to the subject to remind the subject to inject the liquid medicament at a predetermined time.

### Claim 7 (depends on 1)

The method of claim 1, further comprising detecting a difference between a calculated injection duration and an actual injection duration.

### Claim 8 (depends on 7)

The method of claim 7, further comprising analyzing injection data following the injection to determine an error source for the difference between the calculated injection duration and the actual injection duration.

### Claim 9 (depends on 1)

The method of claim 1, wherein the injector is a bolus injector, and wherein the bolus injector is wearable by the subject.

### Claim 10

An injector assembly for automatically delivering a dose of a liquid medicament in a controlled manner, comprising:
a dose module comprising a cartridge housing a hypodermic syringe, wherein the hypodermic syringe contains the dose of the liquid medicament, and wherein the hypodermic syringe is coupled to a hypodermic needle;
an injector having an internal cavity for receiving the cartridge, the injector comprising:
a motor configured to move the hypodermic needle from a retracted position to an extended position;
a power source;
a controller in communication with the power source and a plurality of sensors, the controller having instruction for causing the injector to:
receive input from the plurality of sensors to define one or more injection parameters, and
calculate an injection force for delivering the dose of the liquid medicament in a controlled manner, wherein calculating the injection force comprises calculating a viscosity of the liquid medicament using at least a rheology program stored in a memory of the injector assembly, and wherein the rheology program is specific to the liquid medicament.

### Claim 11 (depends on 10)

The injector assembly of claim 10, wherein the instructions for causing the injector to receive input comprises instructions for obtaining an injection speed for delivery of the dose of the liquid medicament from the cartridge.

### Claim 12 (depends on 10)

The injector assembly of claim 10, wherein the instructions for causing the injector to receive input comprises instructions for detecting a temperature of the dose of the liquid medicament.

### Claim 13 (depends on 10)

The injector assembly of claim 10, wherein the injector further comprises a radio transceiver for transmitting data related to a delivery of a dose of the liquid medicament.

### Claim 14 (depends on 10)

The injector assembly of claim 10, wherein the injector further comprises a drive mechanism operably coupled to the controller, and wherein the controller controls the drive mechanism such that a speed of the motor is controlled based on the calculated injection force.

### Claim 15 (depends on 10)

The injector assembly of claim 10, wherein the injector is a bolus injector.