# US 11,077,252 B2 · Drug container

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- Number: US 11,077,252 B2
- Document ID: US11077252B2
- Status: Granted
- Kind: B2
- Application number: 16/138,784
- Filed: 2018-09-21
- Published: 2019-01-24
- Granted: 2021-08-03
- Earliest claimed: 2016-03-24
- Assignees: Terumo Kabushiki Kaisha
- Applicants: Terumo Kabushiki Kaisha
- Inventors: Sayaka Maruyama; Yoshihiko Abe
- Web page: https://patentgrep.com/patent/US11077252B2

## CPC

- A61J 1/1468: {Containers characterised by specific material properties}
- A61M 5/3134: {characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula}
- A61J 1/05: for collecting, storing or administering blood, plasma or medical fluids {(multiple bags systems for separating or storing blood components A61M1/0209); Infusion or perfusion containers}
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 45/00: Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61M 5/31: Details
- A61M 5/3129: {Syringe barrels (A61M5/3205, A61M5/50 take precedence)}
- C08K 5/20: Carboxylic acid amides
- A61M 2005/3131: {specially adapted for improving sealing or sliding}
- A61M 2205/02: characterised by a particular materials
- A61M 2207/00: Methods of manufacture, assembly or production
- C08K 5/098: Metal salts of carboxylic acids
- C08K 5/101: of monocarboxylic acids
- Y10T 428/1352: Polymer or resin containing [i.e., natural or synthetic]
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08K: Use of inorganic or non-macromolecular organic substances as compounding ingredients (paints, inks, varnishes, dyes, polishes, adhesives C09)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A drug container includes a container body formed of a thermoplastic resin containing a cyclic polyolefin as a main component. The thermoplastic resin contains, as a lubricant, at least one compound selected from among a metal soap compound, an organic fatty acid ester compound, a synthetic wax compound, and a fatty acid amide compound. The lubricant content of the thermoplastic resin is 0.3 to 2.0 μg/g.

## Claims

### Claim 1

A drug container comprising a container body formed of a thermoplastic resin containing a cyclic polyolefin as a main component,
wherein said thermoplastic resin contains, as a lubricant, a fatty acid amide compound,
wherein a lubricant content of said thermoplastic resin is 0.3 to 2.0 μg/g, and
wherein said drug container is autoclave sterilized.

### Claim 2 (depends on 1)

A drug container according to claim 1, wherein said fatty acid amide compound is at least one compound selected from among lauramide, myristamide, palmitamide, stearamide, behenamide, oleamide, erucamide, ethylenebisstearamide, ethylenebisbehenamide, ethylenebisoleamide, and ethylenebiserucamide.

### Claim 3 (depends on 1)

A drug container according to claim 1, wherein said lubricant is erucamide or stearamide.

### Claim 4 (depends on 1)

A drug container according to claim 1, wherein said lubricant contains at least erucamide, and the amount of said erucamide is 30 to 90 wt. % relative to the total amount of said lubricant.

### Claim 5 (depends on 1)

A drug container according to claim 1, wherein said drug container comprises a syringe barrel forming said container body, a gasket disposed in said syringe barrel, and a sealing member that seals a front-end portion of said syringe barrel.

### Claim 6 (depends on 1)

A drug container according to claim 1, wherein said drug container comprises said container body, and a sealing member that seals an opening of said container body.

### Claim 7 (depends on 1)

A drug container according to claim 1, wherein said drug container comprises a medical liquid filled in said container body.

### Claim 8 (depends on 7)

A drug container according to claim 7, wherein said medical liquid is a drug.

### Claim 9 (depends on 8)

A drug container according to claim 8, wherein said drug is a protein solution formulation.

### Claim 10 (depends on 1)

A drug container according to claim 1, wherein said drug container comprises a drug filled in said container body, wherein and said lubricant is erucamide or stearamide.

### Claim 11 (depends on 1)

A drug container according to claim 1, wherein said lubricant content of said thermoplastic resin is 0.5 to 1.5 μg/g.