# US 11,077,227 B2 · Ultrahigh ductility, novel Mg—Li based alloys for biomedical applications > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,077,227 B2 - Document ID: US11077227B2 - Status: Granted - Kind: B2 - Application number: 15/532,149 - Filed: 2015-12-09 - Published: 2017-09-21 - Granted: 2021-08-03 - Earliest claimed: 2014-12-12 - Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education - Applicants: University of Pittsburgh—of the Commonwealth System of Higher Education - Inventors: Prashant N. Kumta; Jingyao Wu; Oleg Velikokhatnyi - Web page: https://patentgrep.com/patent/US11077227B2 ## CPC - A61L 27/30: Inorganic materials - A61L 27/047: {Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06} - A61L 27/306: {Other specific inorganic materials not covered by A61L27/303 - A61L27/32} - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 31/022: {Metals or alloys} - A61L 31/082: {Inorganic materials} - A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - C22C 23/00: Alloys based on magnesium - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C22C: ALLOYS (treatment of alloys C21D, C22F) ## Abstract The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also relates to methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, such as but not limited to, orthopedic, dental, craniofacial and cardiovascular surgery. ## Claims ### Claim 1 A biodegradable medical implant device composed of a ductile, dual phase magnesium-based alloy, consisting of: the dual phase-magnesium-based alloy having co-existing alpha and beta phases, selected from the group consisting of: (i) 9.00% by weight lithium based on total weight of the alloy; 0.96% by weight zinc based on total weight of the alloy; 0.01% by weight aluminum based on total weight of the alloy; and a remainder of magnesium, or (ii) 8.99% by weight lithium based on total weight of the alloy; 0.87% by weight zinc based on total weight of the alloy; 1.07% by weight aluminum based on total weight of the alloy; and a remainder of magnesium, or (iii) 6.11% by weight lithium based on total weight of the alloy; 0.92% by weight zinc based on total weight of the alloy; 0.04% by weight aluminum based on total weight of the alloy; and a remainder of magnesium; and optionally, an active agent, wherein each of the alloys (i), (ii) and (iii) exhibits an elongation of about 48%, about 50% and about 45%, respectively. ### Claim 2 (depends on 1) The medical implant device of claim 1, consisting of the active agent. ### Claim 3 A coated, biodegradable medical implant device, consisting essentially of: a substrate; and a coating deposited on the substrate, the coating consisting of: a ductile, dual phase-magnesium-based alloy having co-existing alpha and beta phases, selected from the group consisting of: (i) 9.00 by weight lithium based on total weight of the alloy; 0.96% by weight zinc based on total weight of the alloy; 0.01% by weight aluminum based on total weight of the alloy; and a remainder of magnesium, or (ii) 8.99% by weight lithium based on total weight of the alloy; 0.87% by weight zinc based on total weight of the alloy; 1.07% by weight aluminum based on total weight of the alloy; and a remainder of magnesium, or (iii) 6.11% by weight lithium based on total weight of the alloy; 0.92% by weight zinc based on total weight of the alloy; 0.04% by weight aluminum based on total weight of the alloy; and a remainder of magnesium, wherein each of the alloys (i), (ii) and (iii) exhibits an elongation of about 48%, about 50% and about 45%, respectively. ### Claim 4 (depends on 3) The coated medical implant device of claim 3, wherein the plasticity and ductility of said device exceeds plasticity and ductility of devices composed of magnesium containing alloys absent lithium. ### Claim 5 (depends on 3) The coated medical implant device of claim 3, wherein said device is effective for use in orthopedic, dental, craniofacial and cardiovascular surgeries. ### Claim 6 (depends on 3) The coated medical implant device of claim 3, wherein the said device is effective to release lithium ions as a therapeutic drug eluting device. ### Claim 7 (depends on 1) The biodegradable medical implant device of claim 1, wherein the device is selected from the group consisting of a stent, suture, wire or staple. ### Claim 8 (depends on 3) The biodegradable medical implant device of claim 3, wherein the device is selected from the group consisting of a stent, suture, wire or staple.