# US 11,077,192 B2 · Methods for photodynamic therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,077,192 B2 - Document ID: US11077192B2 - Status: Granted - Kind: B2 - Application number: 16/438,702 - Filed: 2019-06-12 - Published: 2019-09-26 - Granted: 2021-08-03 - Earliest claimed: 2018-01-12 - Assignees: DUSA Pharmaceuticals, Inc. - Applicants: DUSA Pharmaceuticals, Inc. - Inventors: Scott Lundahl; Michael Guttadauro - Web page: https://patentgrep.com/patent/US11077192B2 ## CPC - A61K 41/0061: {5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA} - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 9/08: Solutions {(composition of solutions A61K47/00)} - A61K 31/75: of ethene - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent} - A61P 17/12: Keratolytics, e.g. wart or anti-corn preparations - A61N 2005/0633: {Arrangements for lifting or hinging the frame which supports the light sources} - A61N 2005/0642: {Irradiating part of the body at a certain distance} - A61N 2005/0652: {Arrays of diodes} - A61N 2005/0659: {infrared} - A61N 2005/0663: {Coloured light} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area. ## Claims ### Claim 1 A method of photodynamic treatment of actinic keratosis, comprising: applying 5-aminolevulinic acid (ALA) in gel form to an actinic keratotic lesion on the stratum corneum of an upper extremity; and reducing evaporation from a portion of the stratum corneum including an area where the lesion is present using an occlusive dressing, wherein reducing evaporation comprises applying the occlusive dressing to the area and keeping the occlusive dressing on the area at a temperature between about 19° C. to about 22° C. ### Claim 2 (depends on 1) The method of claim 1, wherein reducing evaporation comprises applying a low density polyethylene wrap as the occlusive dressing and holding the low density polyethylene wrap in place with an elastic net. ### Claim 3 (depends on 1) The method of claim 1, wherein reducing evaporation comprises applying the occlusive dressing to the area, and securing the occlusive dressing by a tubular elastic stretch netting. ### Claim 4 (depends on 1) The method of claim 1, further comprising illuminating the lesion with a dose of light of 37 J/cm2. ### Claim 5 (depends on 1) The method of claim 1, further comprising covering the occlusive dressing with material. ### Claim 6 (depends on 5) The method of claim 5, wherein covering the occlusive dressing with material comprises placing the material over and around the occlusive dressing. ### Claim 7 A method of photodynamic treatment of actinic keratosis, comprising: applying 5-aminolevulinic acid (ALA) in gel form to an actinic keratotic lesion on the stratum corneum of an upper extremity; and reducing evaporation from a portion of the stratum corneum including an area where the lesion is present using an occlusive dressing, wherein reducing evaporation further comprises keeping the occlusive dressing on the area at a temperature between about 19° C. to about 22° C. ### Claim 8 (depends on 7) The method of claim 7, wherein reducing evaporation comprises applying a low density polyethylene wrap as the occlusive dressing and holding the low density polyethylene wrap in place with an elastic net. ### Claim 9 (depends on 7) The method of claim 7, wherein reducing evaporation comprises applying the occlusive dressing to the area, and securing the occlusive dressing by a tubular elastic stretch netting. ### Claim 10 (depends on 7) The method of claim 7, further comprising illuminating the lesion with a dose of light of 37 J/cm2. ### Claim 11 (depends on 7) The method of claim 7, further comprising covering the occlusive dressing with material. ### Claim 12 (depends on 11) The method of claim 11, wherein covering the occlusive dressing with material comprises placing the material over and around the occlusive dressing. ### Claim 13 A method of photodynamic treatment of actinic keratosis, comprising: applying a topical composition of 5-aminolevulinic acid (ALA) hydrochloride at a concentration of 20% by weight to an actinic keratotic lesion on the stratum corneum of an upper extremity; and reducing evaporation from a portion of the stratum corneum including an area where the lesion is present using an occlusive dressing, wherein reducing evaporation comprises applying the occlusive dressing to the area and keeping the occlusive dressing on the area at a temperature between about 19° C. to about 22° C. ### Claim 14 (depends on 13) The method of claim 13, further comprising covering the occlusive dressing with material.