# US 11,077,191 B2 · Multimodal therapy for cancer cell destruction

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- Number: US 11,077,191 B2
- Document ID: US11077191B2
- Status: Granted
- Kind: B2
- Application number: 15/279,726
- Filed: 2016-09-29
- Published: 2017-05-11
- Granted: 2021-08-03
- Earliest claimed: 2015-10-01
- Assignees: Southeast Missouri State University
- Applicants: Southeast Missouri State University
- Inventors: Santaneel Ghosh; Somesree GhoshMitra
- Web page: https://patentgrep.com/patent/US11077191B2

## CPC

- A61K 41/0052: {Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy}
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/242: Gold; Compounds thereof
- A61K 33/243: Platinum; Compounds thereof
- A61K 41/0028: {Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds}
- A61K 47/6923: {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb}
- A61K 47/6933: {the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol}
- A61K 47/6935: {the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.

## Claims

### Claim 1

A nanostructure for cancer cell destruction, the nanostructure comprising:
a cluster of nanoparticles comprising:
at least one core-shell magnetic nanosphere (CSMNS) nanoparticle, at least one capped gold nanoparticle (AuNP), and at least one a cisplatin loaded thermo-responsive polymeric nanoparticle (CPNP), wherein the cisplatin is loaded inside the CPNP.

### Claim 2 (depends on 1)

The nanostructure of claim 1, wherein the at least one CPNP comprises multiple shells.

### Claim 3 (depends on 1)

The nanostructure of claim 1, wherein the at least one capped AuNP is capped with a material comprising at least one of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), poly(N-isopropylacrylamide) (PNIPAM), dextran, dimercaptosuccinic acid (DMSA) and combinations thereof.

### Claim 4 (depends on 1)

The nanostructure of claim 1, wherein the at least one CSMNS nanoparticle has a diameter of from 50 nm to 400 nm.

### Claim 5 (depends on 1)

The nanostructure of claim 1, wherein the at least one CPNP comprises an inner shell and an outer shell, the inner shell having a diameter of from 50 nm to 300 nm and the outer shell having a diameter of from 50 nm to 400 nm.

### Claim 6

A multimodal method of cancer cell destruction, the method comprising:
applying optical irradiation induced temperature change to at least one nanostructure comprising a cluster of nanoparticles;
simultaneously applying an oscillating magnetic field to the at least one nanostructure, wherein the cluster of nanoparticles comprises at least one core-shell magnetic nanosphere (CSMNS) nanoparticle, at least one capped gold nanoparticle (AuNP), and at least one thermo-responsive polymeric nanoparticle comprising cisplatin (CPNP), and wherein the simultaneous optical irradiation induced temperature change and oscillating magnetic field application creates a sustained release of the cisplatin from the CPNP; and,
interacting the released cisplatin with at least one cancer cell to destroy the cell.

### Claim 7 (depends on 6)

The method of claim 6, wherein the simultaneous irradiation and application of the oscillating magnetic field occur with an incubator-actuator device.

### Claim 8 (depends on 6)

The method of claim 6, wherein the magnetic field has an intensity of from 0 Oe to 150 Oe.

### Claim 9 (depends on 6)

The method of claim 6, wherein the magnetic field has a frequency of from 0 kHz to 1,000 kHz.

### Claim 10 (depends on 6)

The method of claim 6, wherein the nanostructure comprises the at least one CPNP at a concentration of from 50 μg/ml to 600 μg/ml.

### Claim 11 (depends on 6)

The method of claim 6, wherein the at least one CPNP comprises multiple shells.