# US 11,077,170 B2 · Antimicrobial peptide from skate skin and uses thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,077,170 B2 - Document ID: US11077170B2 - Status: Granted - Kind: B2 - Application number: 16/648,043 - Filed: 2018-09-07 - Published: 2020-08-13 - Granted: 2021-08-03 - Earliest claimed: 2017-09-22 - Assignees: Industry-Academic Cooperation Foundation, Chosun University - Applicants: Industry-Academic Cooperation Foundation, Chosun University - Inventors: Yoonkyung Park; Jong-Kook Lee - Web page: https://patentgrep.com/patent/US11077170B2 ## CPC - A61K 38/1706: {from fish} - A01N 33/08: containing oxygen or sulfur - A01N 37/46: N-acyl derivatives - A23B 2/7295: {Antibiotics} - A23B 2/762: Organic compounds containing nitrogen - A23K 20/147: Polymeric derivatives, e.g. peptides or proteins - A23K 20/195: Antibiotics - A23K 50/10: for ruminants - A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof - A61K 31/165: having aromatic rings, e.g. colchicine, atenolol, progabide - A61K 31/43: Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula [IMAGE cpc-sch-A61K-0952.gif], e.g. penicillins, penems - A61K 31/7036: having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins - A61Q 19/00: Preparations for care of the skin - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES - A23K: FODDER - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract A method for treating a microorganism or inflammation caused by the microorganism includes administering or applying a composition comprising an antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 to a subject in need thereof. Because the antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 exhibits an excellent antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria and also low cytotoxicity for human erythrocytes, it can be advantageously used for various applications. ## Claims ### Claim 1 A method for treating a microorganism infection or inflammation caused by the microorganism, the method comprising administering or applying a composition comprising an antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 to a subject in need thereof. ### Claim 2 (depends on 1) The method of claim 1, wherein the microorganism comprises at least one of Gram-negative bacteria and Gram-positive bacteria. ### Claim 3 (depends on 1) The method of claim 1, wherein the microorganism comprises Gram-negative bacteria selected from the group consisting of Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. ### Claim 4 (depends on 1) The method of claim 1, wherein the microorganism comprises Escherichia coli. ### Claim 5 (depends on 1) The method of claim 1, wherein the microorganism comprises Pseudomonas aeruginosa. ### Claim 6 (depends on 1) The method of claim 1, wherein the microorganism comprises Acinetobacter baumannii. ### Claim 7 (depends on 1) The method of claim 1, wherein the microorganism comprises Staphylococcus aureus. ### Claim 8 (depends on 1) The method of claim 1, wherein the composition is an antibiotic composition comprising the antimicrobial peptide and additional antibiotics other than the antimicrobial peptide. ### Claim 9 (depends on 8) The method of claim 8, wherein the antibiotics comprises at least one selected from the group consisting of aminoglycoside-based antibiotics, penicillin-based antibiotics, sulfonamide-based antibiotics, beta-lactam based antibiotics, chloramphenicol-based antibiotics, erythromycin-based antibiotics, florfenicol-based antibiotics, fosfmycin-based antibiotics, kanamycin-based antibiotics, lincomycin-based antibiotics, meticillin-based antibiotics, quinolone-based antibiotics, streptomycin-based antibiotics, tetracycline-based antibiotics, trimethoprim-based antibiotics, and vancomycin-based antibiotics. ### Claim 10 (depends on 1) The method of claim 1, wherein the composition is a quasi-drug composition comprising the antimicrobial peptide and a quasi-drug component. ### Claim 11 (depends on 10) The method of claim 10, wherein quasi-drug component comprises at least one selected from the group consisting of a sterilizing cleanser, a shower foam, a mouth wash, a water tissue, a liquid soap, a hand wash, a humidifier filler, a mask, an ointment, a patch, and a filter filler. ### Claim 12 (depends on 1) The method of claim 1, wherein the composition is a cosmetic composition comprising the antimicrobial peptide and a cosmetic component. ### Claim 13 (depends on 12) The method of claim 12, wherein the cosmetic component comprises at least one selected from the group consisting of an anti-oxidant, a stabilizing agent, a solubilizing agent, a vitamin, a pigment, a fragrance, and a carrier. ### Claim 14 (depends on 12) The method of claim 12, wherein the antimicrobial peptide is in an amount of 0.1 to 50% by weight based on the total weight of the antibiotic cosmetic composition. ### Claim 15 (depends on 12) The method of claim 12, wherein the cosmetic composition is in a formulation selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing cleanser, an oil, a powder foundation, an emulsion foundation, a wax foundation, and a spray. ### Claim 16 (depends on 1) The method of claim 1, wherein the composition is a food comprising the antimicrobial peptide and a food additive component. ### Claim 17 (depends on 1) The method of claim 1, wherein the composition is an animal feed comprising the antimicrobial peptide and an animal feed component. ### Claim 18 (depends on 1) The method of claim 1, wherein the composition is an antibiotic biopesticides comprising the antimicrobial peptide and a biopesticide component. ### Claim 19 (depends on 1) The method of claim 1, wherein the composition is a preservative composition comprising the antimicrobial peptide and a preservative agent.