# US 11,077,167 B2 · Agent for promoting skeletal muscle injury repair

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- Number: US 11,077,167 B2
- Document ID: US11077167B2
- Status: Granted
- Kind: B2
- Application number: 16/619,879
- Filed: 2018-06-12
- Published: 2020-07-02
- Granted: 2021-08-03
- Earliest claimed: 2017-06-15
- Assignees: Osaka University
- Applicants: Osaka University
- Inventors: Susumu Tanaka; Mikihiko Kogo; Hirofumi Yamamoto; Naomasa Kawaguchi; Yoshinosuke Hamada
- Web page: https://patentgrep.com/patent/US11077167B2

## CPC

- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A61K 38/19: Cytokines; Lymphokines; Interferons
- A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K 7/06: having 5 to 11 amino acids
- C07K 14/52: Cytokines; Lymphokines; Interferons
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention provides an agent for promoting skeletal muscle injury repair which agent comprises at least one peptide selected from the following (1) to (4): (1) a peptide consisting of the amino acid sequence of SEQ ID NO: 1, (2) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, (3) a peptide consisting of the amino acid sequence of SEQ ID NO: 3, and (4) a peptide which is a human osteopontin fragment and has the amino acid sequence of SEQ ID NO: 1, 2, or 3 at the C-terminus, or a salt thereof as an active ingredient.

## Claims

### Claim 1

A method for promoting skeletal muscle injury repair, the method comprising administering at least one peptide selected from the following (1) to (3):
(1) a peptide consisting of the amino acid sequence of SEQ ID NO: 1,
(2) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, or
(3) a peptide consisting of the amino acid sequence of SEQ ID NO: 3, or a salt thereof to a mammal having skeletal muscle injury.

### Claim 2 (depends on 1)

The method for promoting skeletal muscle injury repair according to claim 1, wherein the method is capable of promoting satellite cell activation and/or differentiation.

### Claim 3 (depends on 1)

The method for promoting skeletal muscle injury repair according to claim 1, wherein the skeletal muscle injury is muscle rupture, muscle atrophy, or muscle degeneration.

### Claim 4 (depends on 1)

The method for promoting skeletal muscle injury repair according to claim 1, wherein the method is capable of reducing scar formation at a skeletal muscle injury site.

### Claim 5

A method for promoting satellite cell activation and/or differentiation at a skeletal muscle injury site, the method comprising administering at least one peptide selected from the following (1) to (3):
(1) a peptide consisting of the amino acid sequence of SEQ ID NO: 1,
(2) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, or
(3) a peptide consisting of the amino acid sequence of SEQ ID NO: 3, or a salt thereof to a mammal having skeletal muscle injury.

### Claim 6

A method for reducing scar formation at a skeletal muscle injury site, the method comprising administering at least one peptide selected from the following (1) to (3):
(1) a peptide consisting of the amino acid sequence of SEQ ID NO: 1,
(2) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, or
(3) a peptide consisting of the amino acid sequence of SEQ ID NO: 3, or a salt thereof to a mammal having skeletal muscle injury.