# US 11,077,166 B2 · Nutritional supplements containing a peptide component and uses thereof

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- Number: US 11,077,166 B2
- Document ID: US11077166B2
- Status: Granted
- Kind: B2
- Application number: 16/377,594
- Filed: 2019-04-08
- Published: 2019-07-25
- Granted: 2021-08-03
- Earliest claimed: 2013-03-15
- Assignees: Mead Johnson Nutrition Company
- Applicants: Mead Johnson Nutrition Company
- Inventors: Eric A. F. van Tol; Marieke H. Schoemaker; Gabriele Gross; Teartse Tim Lambers; Peter Wielinga; Robert Kleemann
- Web page: https://patentgrep.com/patent/US11077166B2

## CPC

- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/12: Fatty acids or derivatives thereof
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A23L 33/18: Peptides; Protein hydrolysates
- A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557)
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61K 38/06: Tripeptides
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 13/12: of the kidneys
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2400/175: Rhamnosus
- A61K 2035/115: {Probiotics}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.

## Claims

### Claim 1

A nutritional supplement, comprising:
a source of long-chain polyunsaturated fatty acid;
Lactobacillus rhamnosus GG; and
a protein equivalent source,
wherein 20% to 80% of the protein equivalent source includes a peptide component comprising at least 5 individual peptides selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 29, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46, SEQ ID NO: 47, SEQ ID NO: 48, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 52, SEQ ID NO: 53, SEQ ID NO: 54, SEQ ID NO: 55, SEQ ID NO: 56, SEQ ID NO: 58, SEQ ID NO: 59, SEQ ID NO: 61, SEQ ID NO: 62, and SEQ ID NO: 64, and
at least 3 individual peptides selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 13, SEQ ID NO: 17, SEQ ID NO: 21, SEQ ID NO: 24, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 51, SEQ ID NO: 57, SEQ ID NO: 60, and SEQ ID NO: 63, and
wherein 20% to 80% of the protein equivalent source comprises partially hydrolyzed protein.

### Claim 2 (depends on 1)

The nutritional supplement of claim 1, comprising at least 10 additional peptides selected from Table 1.

### Claim 3 (depends on 1)

The nutritional supplement of claim 1, wherein the protein equivalent source comprises casein hydrolysate having a molar mass distribution of greater than 500 Daltons.

### Claim 4 (depends on 1)

The nutritional supplement of claim 1, wherein the protein equivalent source comprises partially hydrolyzed protein having a degree of hydrolysis of less than 40%.

### Claim 5 (depends on 1)

The nutritional supplement of claim 1, further comprising at least one prebiotic.

### Claim 6 (depends on 1)

The nutritional supplement of claim 1, further comprising a culture supernatant from a late-exponential growth phase of a probiotic batch-cultivation process.

### Claim 7 (depends on 1)

The nutritional supplement of claim 1, further comprising at least one probiotic.

### Claim 8 (depends on 1)

The nutritional supplement of claim 1, wherein the at least one long-chain polyunsaturated fatty acid is selected from the group consisting of docosahexaenoic acid and arachidonic acid.

### Claim 9 (depends on 1)

The nutritional supplement of claim 1, wherein when administered to a subject, the nutritional supplement promotes a healthy weight, promotes a healthy body fat mass, lowers plasma cholesterol levels, lowers plasma triglycerides, or any combination thereof.

### Claim 10 (depends on 1)

The nutritional supplement of claim 1, wherein the peptide component is present in an amount from about 0.2 g/100 kcal to about 5.6 g/100 kcal.

### Claim 11 (depends on 1)

The nutritional supplement of claim 1, further comprising β-glucan.

### Claim 12 (depends on 1)

The nutritional supplement of claim 1, wherein the nutritional composition further comprises intact protein.

### Claim 13 (depends on 1)

The nutritional supplement of claim 1, further comprising a carbohydrate source.

### Claim 14 (depends on 13)

The nutritional supplement of claim 13, wherein the carbohydrate source is present in an amount of from about 5 g/100 kcal to about 25 g/100 kcal.

### Claim 15 (depends on 1)

The nutritional supplement of claim 1, further comprising a fat or lipid source.

### Claim 16 (depends on 15)

The nutritional supplement of claim 15, wherein the fat or lipid source is present in an amount of from about 1.3 g/100 kcal to about 7.2 g/100 kcal.