# US 11,077,162 B2 · Heart-protective plant preparation for preventing and improving coronary heart disease

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- Number: US 11,077,162 B2
- Document ID: US11077162B2
- Status: Granted
- Kind: B2
- Application number: 17/120,162
- Filed: 2020-12-12
- Published: 2021-04-01
- Granted: 2021-08-03
- Earliest claimed: 2018-12-11
- Assignees: Shandong University of Technology
- Applicants: Shandong University of Technology
- Inventors: Yuanda Song; Syed Ammar; Shaoqi Li; Wu Yang
- Web page: https://patentgrep.com/patent/US11077162B2

## CPC

- A61K 36/9068: Zingiber, e.g. garden ginger
- A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48)
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/14: Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)}
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/22: Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
- A61K 36/287: Chrysanthemum, e.g. daisy
- A61K 36/31: Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K 36/45: Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
- A61K 36/49: Fagaceae (Beech family), e.g. oak or chestnut
- A61K 36/52: Juglandaceae (Walnut family)
- A61K 36/537: Salvia (sage)
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/5777: {Theobroma, e.g. cocao or cocoa}
- A61K 36/60: Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K 36/63: Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K 36/71: Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K 36/738: Rosa (rose)
- A61K 36/889: Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
- A61K 36/8962: Allium, e.g. garden onion, leek, garlic or chives
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/06: Antihyperlipidemics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 9/14: Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- A61P 25/22: Anxiolytics
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K 2236/333: using mixed solvents, e.g. 70% EtOH
- A61K 2236/51: Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present disclosure provides a natural plant preparation, including extracts of the following parts of plants: roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., Walnut and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp. The present disclosure further provides a method for preparing a plant preparation, including treating the above parts of plants with ethanol.

## Claims

### Claim 1

A plant preparation, comprising in an oral dosage form therapeutically effective amounts of ethanol extracts of following parts of plants:
roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., walnut, and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp.

### Claim 2 (depends on 1)

The plant preparation according to claim 1, comprising:
15-25 parts by weight of roots of Salvia miltiorrhiza Bunge,
5-15 parts by weight of roots of Juglans regia,
15-25 parts by weight of roots of Aesculus hippocastanum L.,
5-15 parts by weight of roots of Zingiber officinale Rosc.,
5-15 parts by weight of barks of Cinnamomum cassia Presl,
5-15 parts by weight of seeds of Sesamum indicum,
5-15 parts by weight of seeds of Carica papaya L.,
15-25 parts by weight of seeds of Nigella damascena L.,
5-15 parts by weight of seeds of Punica granatum L.,
15-25 parts by weight of leaves of Centaurea cyanus L.,
5-15 parts by weight of resin of Pistacia Lentiscus,
5-15 parts by weight of drupes of Cocos nucifera L.,
5-15 parts by weight of beans of Theobroma cacao L.,
5-15 parts by weight of dried pulp of Phoenix dactylifera L.,
5-15 parts by weight of kernels of Phoenix dactylifera L.,
5-15 parts by weight of dried pulp of Olea europaea,
5-15 parts by weight of dried pulp of Ficus carica Linn.,
5-15 parts by weight of walnut,
5-15 parts by weight of dried pulp of Vaccinium spp,
5-15 parts by weight of cloves of Allium sativum, and
5-15 parts by weight of petals of Rosa sp.

### Claim 3 (depends on 2)

The plant preparation according to claim 2, comprising the ethanol extracts of the following parts of plants:
20 parts by weight of roots of Salvia miltiorrhiza Bunge,
10 parts by weight of roots of Juglans regia,
20 parts by weight of roots of Aesculus hippocastanum L.,
10 parts by weight of roots of Zingiber officinale Rosc.,
10 parts by weight of barks of Cinnamomum cassia Presl,
10 parts by weight of seeds of Sesamum indicum,
10 parts by weight of seeds of Carica papaya L.,
20 parts by weight of seeds of Nigella damascena L.,
10 parts by weight of seeds of Punica granatum L.,
20 parts by weight of leaves of Centaurea cyanus L.,
10 parts by weight of resin of Pistacia Lentiscus,
10 parts by weight of drupes of Cocos nucifera L.,
10 parts by weight of beans of Theobroma cacao L.,
10 parts by weight of dried pulp of Phoenix dactylifera L.,
10 parts by weight of kernels of Phoenix dactylifera L.,
10 parts by weight of dried pulp of Olea europaea,
10 parts by weight of dried pulp of Ficus carica Linn.,
10 parts by weight of walnut,
10 parts by weight of dried pulp of Vaccinium Spp,
10 parts by weight of cloves of Allium sativum, and
10 parts by weight of petals of Rosa sp.

### Claim 4 (depends on 1)

The plant preparation according to claim 1, wherein the plant preparation is formulated into a dosage form selected from the group consisting of powders, capsules, tablets, granules, pills, and lozenges.

### Claim 5 (depends on 1)

A method for preparing a plant preparation according to claim 1, the method comprising the steps of:
providing parts of plants comprising roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., walnut, and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp.
treating the parts of the plants, at 70-80° C., with ethanol, and
maintaining pH of the resulting solution between pH 7 and pH 10.

### Claim 6 (depends on 5)

The method according to claim 5, wherein the ethanol is 60-80 vol % ethanol or 70 vol % ethanol.

### Claim 7 (depends on 5)

The method according to claim 5, wherein the provided parts of plants are in powder form.

### Claim 8 (depends on 5)

The method according to claim 5, wherein the duration for treating the parts of plants with ethanol is 16-20 h.

### Claim 9 (depends on 5)

The method according to claim 5, further comprising a drying step to remove the organic solvents and/or provide the plant preparation as a dried plant preparation.

### Claim 10 (depends on 5)

The method according to claim 5, wherein the drying step comprises drying by a hot air oven to evaporate organic solvents followed by freeze drying.