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US 11,077,122 B2Granted
Non-bioconvertible C3-substituted pregnenolone derivatives for use in the treatment of substance use disorders
AssigneeMapreg
InventorsGeorge F. Koob, Barbara Jean Mason, Olivier George, Etienne Baulieu, Isabelle Villey
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Abstract
The present invention relates to the use of non-bioconvertible C3-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.
Claims5
A method for treating or preventing relapse of alcohol use disorder in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a compound 3-methoxy-pregna-5-ene-20-one of formula:
- or a pharmaceutically acceptable salt thereof, wherein the subject does not have depression and has not had depression prior to said administration.
Dependencies are inferred from the claim text.