# US 11,077,120 B2 · Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto

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- Number: US 11,077,120 B2
- Document ID: US11077120B2
- Status: Granted
- Kind: B2
- Application number: 16/686,046
- Filed: 2019-11-15
- Published: 2020-03-19
- Granted: 2021-08-03
- Earliest claimed: 2014-04-29
- Assignees: Emory University
- Applicants: Emory University
- Inventors: Thota Ganesh; Jianxiong Jiang; Raymond Dingledine
- Web page: https://patentgrep.com/patent/US11077120B2

## CPC

- A61K 31/551: having two nitrogen atoms, e.g. dilazep
- A61K 31/4184: condensed with carbocyclic rings, e.g. benzimidazoles
- A61K 31/4192: 1,2,3-Triazoles
- A61K 31/454: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/506: not condensed and containing further heterocyclic rings
- A61K 31/517: ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol
- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.

## Claims

### Claim 1

A method of treating endometriosis comprising administering an effective amount of N-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-(1H-tetrazol-5-yl)benzamide or salt thereof to a subject in need thereof.

### Claim 2

A method of treating arthritis comprising administering an effective amount of N-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-(1H-tetrazol-5-yl)benzamide or salt thereof to a subject in need thereof.

### Claim 3 (depends on 2)

The method of claim 2, wherein the arthritis is rheumatoid arthritis, enthesitis-related arthritis, or psoriatic arthritis.

### Claim 4

A method of treating cancer comprising administering an effective amount of N-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-(1H-tetrazol-5-yl)benzamide or salt thereof to a subject in need thereof.

### Claim 5 (depends on 4)

The method of claim 4 wherein the cancer is skin, blood vessel, lung, head, neck, prostate, colon, ovary, or breast cancer.

### Claim 6 (depends on 4)

The method of claim 4 wherein the cancer is hepatocellular carcinoma.