# US 11,077,089 B2 · Oral compositions delivering therapeutically effective amounts of cannabinoids

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- Number: US 11,077,089 B2
- Document ID: US11077089B2
- Status: Granted
- Kind: B2
- Application number: 16/988,041
- Filed: 2020-08-07
- Published: 2021-01-14
- Granted: 2021-08-03
- Earliest claimed: 2016-06-22
- Assignees: Per Os Biosciences, LLC
- Applicants: Per Os Biosciences, LLC
- Inventors: Robert Estey; William O. Brisben
- Web page: https://patentgrep.com/patent/US11077089B2

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/0058: {Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00)}
- A61K 9/2018: {Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates}
- A61K 9/2095: {Tabletting processes}
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K 36/3482: {Cannabis}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/06: Antimigraine agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Oral compositions provide delivery of cannabinoids to a subject. The oral compare chewable, fast- or slow-dissolving once placed in the mouth of a subject.

## Claims

### Claim 1

A composition comprising:
a sugar, sugar alcohol, or sweeteners, and combinations thereof,
bamboo fibers,
a cannabinoid,
flavorings, and
tableting lubricants or powder flow agents, and combinations thereof, wherein the composition is a powder.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the composition, based on the total weight of the composition, comprises:
about 10% to about 80% by weight of a sugar, sugar alcohol, or sweetener, and combinations thereof,
about 5% to about 50% by weight of bamboo fibers,
about 0.1% to about 20% by weight of a cannabinoid,
about 0.1% to about 10% by weight of flavorings, and
about 0.1% to about 10% by weight of tableting lubricants or powder flow agents, and combinations thereof.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the composition, based on the total weight of the composition, comprises:
about 55% to about 70% by weight of a sugar, sugar alcohol, or sweetener, and combinations thereof,
about 5% to about 20% by weight of bamboo fibers,
about 0.1% to about 10% by weight of a cannabinoid,
about 0.1% to about 5% by weight of flavorings, and
about 0.1% to about 5% by weight of tableting lubricants or powder flow agents, and combinations thereof.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the sugar comprises dextrose, sucrose or a combination thereof.

### Claim 5 (depends on 1)

The composition of claim 1, wherein the sugar alcohol comprises: sorbitol, xylitol, or a combination thereof.

### Claim 6 (depends on 1)

The composition of claim 1, wherein the sweetener comprises sucralose or stevia.

### Claim 7 (depends on 1)

The composition of claim 1, wherein the tableting lubricants and powder flow agents comprises magnesium stearate, silicon dioxide, calcium stearate, stearic acid, talc or rice bran-based excipients and combinations thereof.

### Claim 8

A composition consisting of:
a sugar, sugar alcohol, or sweeteners, and combinations thereof,
bamboo fibers,
a cannabinoid,
flavorings, and
tableting lubricants and powder flow agents,
wherein the composition is a powder.

### Claim 9 (depends on 8)

The composition of claim 8, wherein the composition, based on the total weight of the composition, consists of:
about 55% to about 70% by weight of a sugar, sugar alcohol, or sweetener, and combinations thereof,
about 5% to about 20% by weight of bamboo fibers,
about 0.1% to about 10% by weight of a cannabinoid,
about 0.1% to about 5% by weight of flavorings, and
about 0.1% to about 5% by weight of tableting lubricants and powder flow agents.

### Claim 10

A composition comprising:
a sugar, sugar alcohol, or sweeteners, and combinations thereof,
bamboo fibers,
a cannabidiol (CBD) or tetrahydrocannabinol (THC), and combinations thereof,
flavorings,
tableting lubricants or powder flow agents, and combinations thereof, wherein the composition is a powder.

### Claim 11 (depends on 10)

The composition of claim 10, wherein the composition, based on the total weight of the composition, comprises:
about 10% to about 80% by weight of a sugar, sugar alcohol, or sweetener, and combinations thereof,
about 5% to about 50% by weight of bamboo fibers,
about 0.1% to about 20% by weight of a cannabidiol (CBD), a tetrahydrocannabinol (THC) or combinations thereof,
about 0.1% to about 10% by weight of a flavoring, and
about 0.1% to about 10% by weight of tableting lubricants and powder flow agents.

### Claim 12 (depends on 10)

The composition of claim 10, wherein the composition, based on the total weight of the composition, comprises:
about 55% to about 70% by weight of a sugar, sugar alcohol, or sweetener, and combinations thereof,
about 5% to about 20% by weight of bamboo fibers,
about 0.1% to about 10% by weight of cannabidiol (CBD), tetrahydrocannabinol (THC) or the combination thereof,
about 0.1% to about 5% by weight of flavorings, and
about 0.1% to about 5% by weight of tableting lubricants and powder flow agents.

### Claim 13 (depends on 10)

The composition of claim 10, wherein the sugar comprises dextrose, sucrose or a combination thereof.

### Claim 14 (depends on 10)

The composition of claim 10, wherein the sugar alcohol comprises: sorbitol, xylitol, or a combination thereof.

### Claim 15 (depends on 10)

The composition of claim 10, wherein the sweetener comprises sucralose, monk fruit, neotame, aspartame, acesulfame potassium, licorice extract, stevia, honey or agave nectar, or combinations thereof.

### Claim 16 (depends on 10)

The composition of claim 10, wherein the tableting lubricants and powder flow agents comprise magnesium stearate, silicon dioxide, calcium stearate, stearic acid, talc or rice bran-based excipients and combinations thereof.
