# US 11,077,088 B2 · Composition and apparatus for treatment of chemotherapy induced alopecia

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- Number: US 11,077,088 B2
- Document ID: US11077088B2
- Status: Granted
- Kind: B2
- Application number: 16/312,642
- Filed: 2017-06-20
- Published: 2019-08-08
- Granted: 2021-08-03
- Earliest claimed: 2016-06-22
- Assignees: Paxman Coolers Limited
- Applicants: Paxman Coolers Ltd
- Inventors: Nikolaos Georgopoulos; Andrew Collett; Richard Paxman
- Web page: https://patentgrep.com/patent/US11077088B2

## CPC

- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61F 7/10: Cooling bags, e.g. ice-bags
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61P 17/14: for baldness or alopecia
- A61F 2007/0008: {Scalp}
- A61F 2007/0287: {Preventing negative effects of chemotherapy}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A composition for use in cooling therapy and treatment of chemically induced alopecia (CIA), said composition containing a reactive oxygen species (ROS) inhibitor.

## Claims

### Claim 1

A method for the treatment of chemotherapy induced alopecia to provide protection from drug induced toxicity comprising the steps of: (i) administering topically a composition comprising a reactive oxygen species inhibitor (ROS) to the scalp of a patient (ii) scalp cooling therapy, wherein the ROS inhibitor is selected from N-acetyl-cysteine, Vitamin C, flavonoids, flavonols, quercetin and wherein the ROS inhibitor is cooled after application to temperature of 26° C. or below.

### Claim 2 (depends on 1)

A method according to claim 1 wherein the scalp is cooled using a cap.