# US 11,077,087 B2 · Compositions comprising dihydroquercetin for use in methods for treating herpes

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- Number: US 11,077,087 B2
- Document ID: US11077087B2
- Status: Granted
- Kind: B2
- Application number: 15/558,587
- Filed: 2016-03-18
- Published: 2018-03-01
- Granted: 2021-08-03
- Earliest claimed: 2015-03-18
- Assignees: Bionoox Suisse SA
- Applicants: Bionoox Suisse SA
- Inventors: Christian Auclair
- Web page: https://patentgrep.com/patent/US11077087B2

## CPC

- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 31/22: for herpes viruses
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed is the use of a composition including dihydroquercetin and optionally α-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating HSV infection and the associated inflammation.

## Claims

### Claim 1

A method for treating genital sores or blisters in subjects suffering from genital herpes simplex virus type 2 infection, comprising topically administering once a day during 14 days an effective amount of a composition comprising 5% w/w dihydroquercetin, 1% w/w α-tocopherol, 0.2% w/w bisabolol and a mucosal-compatible base.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the mucosal compatible base in said composition comprises at least one compound selected from the group consisting of animal fat, vegetable fat, higher alcohols, glycols, and mixtures thereof.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said composition further comprises at least one component selected from the group consisting of surfactants, pigments, stabilizers, emollients, humectants, and mixtures thereof.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition is a cream, a gel, an ointment, a solution, an emulsion, an oil-in-water emulsion, a mask, a stick, a milk, a lotion, a serum, a paste, a foam, or a suspension.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the composition is a cream.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the composition is formulated as a stick.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the composition is administered in combination with another treatment for herpes.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the composition is administered in combination with an oral treatment for herpes.