# US 11,077,081 B2 · Amino-acid-containing composition for enhancing recovery from muscle fatigue

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- Number: US 11,077,081 B2
- Document ID: US11077081B2
- Status: Granted
- Kind: B2
- Application number: 14/175,154
- Filed: 2014-02-07
- Published: 2014-06-05
- Granted: 2021-08-03
- Earliest claimed: 2011-08-08
- Assignees: Ajinomoto Co., Inc.
- Applicants: Ajinomoto Co., Inc.
- Inventors: Hiroyuki Kato; Hisamine Kobayashi; Mayu Sugita; Hiromi Suzuki; Masako Mimura
- Web page: https://patentgrep.com/patent/US11077081B2

## CPC

- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A23L 33/175: Amino acids
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Administering an amino acid-containing composition, containing the following amino acids (1)-(9), wherein the molar content ratio of each amino acid to the total content of the amino acids (1)-(9) falls within the following numerical ranges: (1) leucine 35-66%; (2) isoleucine 5.0-15%; (3) valine 5.0-15%; (4) threonine 7.0-14%; (5) lysine 8.0-16%; (6) methionine 2.0-10%; (7) histidine 0.1-3.5%; (8) phenylalanine 2.5-8.0%; and (9) tryptophan 0.1-2.0%, is effective for enhancing recovery from muscle fatigue.

## Claims

### Claim 1

A method of enhancing recovery from muscle weakness caused by muscle damage due to eccentric contraction exercise, comprising: administering to a subject in need thereof an effective amount of an amino acid-containing composition, wherein the amino acid-containing composition comprises, in a molar content ratio with respect to a total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan,
(1) 35 to 66% of leucine,
(2) 5.0 to 15% of isoleucine,
(3) 5.0 to 15% of valine,
(4) 7.0 to 14% of threonine,
(5) 8.0 to 16% of lysine,
(6) 2.0 to 10% of methionine,
(7) 0.1 to 3.5% of histidine,
(8) 2.5 to 8.0% of phenylalanine, and
(9) 0.1 to 2.0% of tryptophan,
wherein the amino acid-containing composition is administered to the subject after the exercise.

### Claim 2 (depends on 1)

The method of claim 1, wherein the amino acid-containing composition comprises 42 to 66% of leucine, 0.1 to 1.1% of histidine, and 2.5 to 5.6% of phenylalanine in the molar content ratio with respect to the total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan.

### Claim 3 (depends on 1)

The method of claim 1, wherein the amino acid-containing composition comprises, in the molar content ratio with respect to the total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan,
(1) about 42% of leucine,
(2) about 11% of isoleucine,
(3) about 13% of valine,
(4) about 11% of threonine,
(5) about 13% of lysine,
(6) about 3% of methionine,
(7) about 1% of histidine,
(8) about 6% of phenylalanine, and
(9) about 1% of tryptophan.

### Claim 4

A method of enhancing recovery of an amount of collagen protein in muscle decreased due to eccentric contraction exercise, comprising: administering to a subject in need thereof an effective amount of an amino acid-containing composition such that recovery of an amount of collagen protein in muscle is enhanced, wherein the amino acid-containing composition comprises, in a molar content ratio with respect to a total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan,
(1) 35 to 66% of leucine,
(2) 5.0 to 15% of isoleucine,
(3) 5.0 to 15% of valine,
(4) 7.0 to 14% of threonine,
(5) 8.0 to 16% of lysine,
(6) 2.0 to 10% of methionine,
(7) 0.1 to 3.5% of histidine,
(8) 2.5 to 8.0% of phenylalanine, and
(9) 0.1 to 2.0% of tryptophan,
wherein the amino acid-containing composition is administered to the subject after the exercise.

### Claim 5 (depends on 4)

The method of claim 4, wherein the amino acid-containing composition comprises, in the molar content ratio with respect to the total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan,
(1) about 42% of leucine,
(2) about 11% of isoleucine,
(3) about 13% of valine,
(4) about 11% of threonine,
(5) about 13% of lysine,
(6) about 3% of methionine,
(7) about 1% of histidine,
(8) about 6% of phenylalanine, and
(9) about 1% of tryptophan.

### Claim 6

A method of enhancing recovery of an amount of desmin protein in muscle decreased due to eccentric contraction exercise, comprising: administering to a subject in need thereof an effective amount of an amino acid-containing composition such that recovery of an amount of desmin protein in muscle is enhanced, wherein the amino acid-containing composition comprises, in a molar content ratio with respect to a total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan,
(1) 35 to 66% of leucine,
(2) 5.0 to 15% of isoleucine,
(3) 5.0 to 15% of valine,
(4) 7.0 to 14% of threonine,
(5) 8.0 to 16% of lysine,
(6) 2.0 to 10% of methionine,
(7) 0.1 to 3.5% of histidine,
(8) 2.5 to 8.0% of phenylalanine, and
(9) 0.1 to 2.0% of tryptophan,
wherein the amino acid-containing composition is administered to the subject after the exercise.

### Claim 7 (depends on 6)

The method of claim 6, wherein the amino acid-containing composition comprises, in the molar content ratio with respect to the total amount of leucine, isoleucine, valine, threonine, lysine, methionine, histidine, phenylalanine, and tryptophan,
(1) about 42% of leucine,
(2) about 11% of isoleucine,
(3) about 13% of valine,
(4) about 11% of threonine,
(5) about 13% of lysine,
(6) about 3% of methionine,
(7) about 1% of histidine,
(8) about 6% of phenylalanine, and
(9) about 1% of tryptophan.

### Claim 8 (depends on 1)

The method of claim 1, wherein an amount of the amino acid-containing composition administered to the subject is from 3 to 22 g.

### Claim 9 (depends on 4)

The method of claim 4, wherein the amount of collagen protein is decreased due to exercise as compared to an amount of collagen protein in muscle in the subject prior to the exercise.

### Claim 10 (depends on 6)

The method of claim 6, wherein the amount of desmin protein is decreased due to exercise as compared to an amount of desmin protein in muscle in the subject.

### Claim 11 (depends on 1)

The method of claim 1, wherein an amount of the amino acid-containing composition administered to the subject is from 6 to 20 g.