# US 11,077,065 B2 · Process for preparing an acid resistant cellulose capsule

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- Number: US 11,077,065 B2
- Document ID: US11077065B2
- Status: Granted
- Kind: B2
- Application number: 16/793,179
- Filed: 2020-02-18
- Published: 2020-09-10
- Granted: 2021-08-03
- Earliest claimed: 2019-02-19
- Assignees: Suheung Co., Ltd.
- Applicants: Suheung Co., Ltd.
- Inventors: Joo-Hwan Yang
- Web page: https://patentgrep.com/patent/US11077065B2

## CPC

- A61K 9/4816: {Wall or shell material}
- A61K 9/4825: {Proteins, e.g. gelatin (gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 47/02: Inorganic compounds
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K 47/38: Cellulose; Derivatives thereof
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A process for preparing an acid resistant cellulose capsule. An example of a process for preparing an acid resistant cellulose capsule includes the steps of: i) preparing 100 wt part of aqueous solution of solubilized cellulose including 15-25 wt part of cellulose; ii) sequentially adding and solubilizing: 2.0-4.0 wt part of amid pectin and 0.1-1.0 wt part of iota-carrageenan as a gelling agent, an auxiliary gelling agent, a pH neutralizing agent, an emulsifying agent, a viscosity stabilizing agent and a plasticizing agent to the resulting admixture; and iii) allowing it to stand and to be equilibrated with adjustment of viscosity, before forming the capsule.

## Claims

### Claim 1

A process for preparing an acid resistant cellulose capsule, the process comprising:
i) preparing 100 wt part of aqueous solution of solubilized cellulose including 15-25 wt part of cellulose;
ii) adding and stirring 2.0-4.0 wt part of amide pectin and 0.1-1.0 wt part of iota-carrageenan as a gelling agent, and 0.01-0.2 wt part of potassium carbonate and 0.01-0.2 wt part of calcium gluconate as an auxiliary gelling agent to the aqueous solution of solubilized cellulose;
iii) sequentially adding and stirring 0.01-0.1 wt part of glacial acetic acid as a pH neutralizing agent, 0.01-0.2 wt part of sucrose fatty acid ester and diacetylated monoglyceride as an emulsifying agent, 0.01-0.1 wt part of colloidal silica as a viscosity stabilizing agent, and 0.01-0.1 wt part of glycerin, PEG 4000 and/or propylene glycol as a plasticizing agent to the resulting admixture to create an obtained product;
iv) allowing the obtained product to stand and to be equilibrated; and
v) forming and drying a cellulose capsule.

### Claim 2 (depends on 1)

The process for preparing an acid resistant cellulose capsule according to claim 1, wherein in said step iv), the obtained product stands at 65° C.; and
wherein forming and drying a cellulose capsule comprises: dipping a molding pin for forming the cellulose capsule, and drying the cellulose capsule at 30-37° C.

### Claim 3 (depends on 1)

The process for preparing an acid resistant cellulose capsule according to claim 1, wherein said amide pectin is low methoxyl amide pectin.

### Claim 4 (depends on 1)

The process for preparing an acid resistant cellulose capsule according to claim 1, wherein said colloidal silica is stable spherical particles having 5-8 wt % of SiO2 content, a pH of 10-12 and a particle size of 2-5 nm.

### Claim 5 (depends on 1)

An acid resistant cellulose capsule prepared by the method of claim 1.

### Claim 6 (depends on 1)

An acid resistant cellulose capsule prepared by the method of claim 1, wherein the dissolution profile shows 8-12 wt % of dissolution of the contents for an initial 120 minutes in a first solution having a pH of 1.2 and 95-100 wt % of subsequent dissolution of the contents for the next 120 minutes in a second solution having a pH of 6.8, according to the paddle method of the dissolution test in the Korean pharmacopoeia 10th Edition.