# US 11,077,039 B2 · Topical skin lightening additive and composition with amino acids and nicotinamide compounds

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- Number: US 11,077,039 B2
- Document ID: US11077039B2
- Status: Granted
- Kind: B2
- Application number: 16/470,391
- Filed: 2017-12-18
- Published: 2020-04-09
- Granted: 2021-08-03
- Earliest claimed: 2016-12-21
- Assignees: Conopco, Inc.
- Applicants: Conopco, Inc.
- Inventors: Anita Damodaran; Annu Kumari; Nan Huang; Tingyan Mi; Bijan Harichian; Jose Guillermo Rosa
- Web page: https://patentgrep.com/patent/US11077039B2

## CPC

- A61K 8/447: {containing sulfur}
- A61K 8/064: {Water-in-oil emulsions, e.g. Water-in-silicone emulsions}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/4913: {having five membered rings, e.g. pyrrolidone carboxylic acid}
- A61K 8/4926: {having six membered rings}
- A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Skin lightening additives and personal care compositions containing amino acids and nicotinamide compounds. The compositions are useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

## Claims

### Claim 1

A topical personal care skin lightening composition comprising:
a. skin lightening additive comprising by weight of the composition:
i. from about 0.005 to about 1% of cystine;
ii. from about 0.01 to about 5% of glutamine;
iii. from about 0.01 to about 5% of glycine; and
iv. from about 0.1 to about 10% of nicotinamide compound; and
b. a cosmetically acceptable carrier in the form of an emulsion;
c. wherein the pH of the composition is in the range of from about 3.5 to about 8.5;
wherein the ratio of nicotinamide to total amino acid is about 20:1 to 50:1.

### Claim 2 (depends on 1)

The composition of claim 1 wherein nicotinamide compound is nicotinamide riboside.

### Claim 3 (depends on 1)

The composition of claim 1 wherein nicotinamide compound is N-methyl nicotinamide.

### Claim 4 (depends on 1)

The composition of claim 1 wherein nicotinamide compound is nicotinamide.

### Claim 5 (depends on 1)

The composition of claim 1 wherein nicotinamide compound is isonicotinamide.

### Claim 6 (depends on 1)

The composition of claim 1 wherein the composition is in the form of a water-in-oil emulsion comprising cystine in an aqueous phase, wherein 90% of the water droplets have a diameter within the size range of from 100 nm to 20 microns.

### Claim 7 (depends on 1)

The composition of claim 1 wherein the composition is a leave-on non-solid skin cosmetic composition.

### Claim 8 (depends on 1)

The composition of claim 1 wherein the composition is a vanishing cream.

### Claim 9 (depends on 1)

The composition of claim 1 wherein the composition further comprises 4-alkyl resorcinol.

### Claim 10 (depends on 1)

The composition of claim 1 wherein the composition further comprises 12-hydroxystearic acid.