# US 11,077,024 B2 · Systems and methods for high humidity curing within tablet coating system

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- Number: US 11,077,024 B2
- Document ID: US11077024B2
- Status: Granted
- Kind: B2
- Application number: 16/549,151
- Filed: 2019-08-23
- Published: 2019-12-12
- Granted: 2021-08-03
- Earliest claimed: 2019-08-23
- Assignees: SpecGX LLC
- Applicants: SpecGX LLC
- Inventors: Greg Bengard
- Web page: https://patentgrep.com/patent/US11077024B2

## CPC

- A61J 3/005: {Coating of tablets or the like (coating of sweetmeats or confectionery A23G3/20; coating of granules in general B01J2/006)}
- A61K 9/2893: {Tablet coating processes (mechanical aspects A61J3/06)}
- B05B 12/12: responsive to conditions of ambient medium or target, e.g. humidity, temperature {position or movement of the target relative to the spray apparatus (B05B12/082, B05B12/084 take precedence)}
- B05B 16/60: Ventilation arrangements specially adapted therefor
- B05D 3/0486: {Operating the coating or treatment in a controlled atmosphere}
- F24F 6/18: by injection of steam into the air
- F24F 13/04: Air-mixing units (F24F13/06 takes precedence)
- F24F 13/08: Air-flow control members, e.g. louvres, grilles, flaps or guide plates (F24F7/013, F24F13/06 take precedence)
- A61J 3/06: into the form of pills, lozenges or dragees
- B05B 13/0257: {in a moving container, e.g. a rotatable foraminous drum}
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B05B: SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES (spray-mixers with nozzles B01F25/72; processes for applying liquids or other fluent materials to surfaces by spraying B05D)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)
- F24F: AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING (removing dirt or fumes from areas where they are produced B08B15/00; vertical ducts for carrying away waste gases from buildings E04F17/02; tops for chimneys or ventilating shafts, terminals for flues F23L17/02)

## Abstract

The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.

## Claims

### Claim 1

A tablet coating system comprising:
a pan coater operable to apply one or more coatings to a tablet; and
a recirculating air handler operable to supply high humidity air flow to the pan coater, the recirculating air handler comprising:
an inlet duct operable to receive exhaust air from the pan coater;
a humidifier to introduce moisture into the exhaust air in an amount resulting in an exit air having a relative humidity of up to about 94%;
a vent operable to release air from the recirculating air handler to the atmosphere via a vent valve, wherein the vent valve is opened as needed to maintain a pressure within the pan coater of at least 0.15 inches of water column below atmospheric pressure;
an exit duct operable to deliver the exit air to the pan coater;
one or more configurable valves; and
a control system comprising a mode control operable to coordinate the opening and closing of the one or more to switch an air supply of the pan coater from a flow-through air handler to the recirculating air handler.

### Claim 2 (depends on 1)

The tablet coating system of claim 1, wherein the recirculating air handler further comprises at least one inlet filter situated upstream of the humidifier to remove particulate matter from an airflow entering the recirculating air handler and at least one exit filter situated downstream of the of the humidifier to remove particulate matter from an airflow exiting the pan coater, and wherein the control system further comprises a filter monitor operable to monitor an operational status of the at least one inlet or exit filter and issue warnings to a system user when a filter is clogged and/or in need of cleaning or replacement.

### Claim 3 (depends on 1)

The tablet coating system of claim 1, wherein the control system is further operable to modulate the air flow within the system, modulate temperature within the system, modulate humidity within the system, and/or modulate pressure within the pan coater.

### Claim 4 (depends on 1)

The tablet coating system of claim 1, further comprising:
a heater operable to heat the pan coater;
a temperature sensor operable to measure the temperature of the air flow downstream of the heater, wherein the control system reduces the heat output of the heater if the temperature of the air flow exceeds a maximum temperature; and
a temperature sensor operable to measure air temperature within the pan coater, wherein the control system is operable to command increased heat output by the heater if the air temperature for the pan coater falls below a predetermined threshold temperature.

### Claim 5 (depends on 1)

The tablet coating system of claim 1, further comprising:
a humidity sensor operable to measure humidity introduced by the humidifier, the humidity sensor operatively connected to the exit duct of the recirculating air handler, wherein the control system is operable to increase or decrease the humidifier output if the measured humidity falls outside a minimum or maximum humidity level; and
an additional humidity sensor within the pan coater, wherein the control system is operable to reduce clean steam flow entering the humidifier if the measured humidity at the additional humidity sensor exceeds a predetermined condensation threshold.

### Claim 6 (depends on 1)

The tablet coating system of claim 1, further comprising a first pressure sensor and a second pressure sensor, wherein the control system comprises a pressure monitor operable to monitor a differential pressure between the first pressure sensor and the second pressure sensor and issue an alert or open a venting valve if the differential pressure exceeds a threshold value.

### Claim 7 (depends on 6)

The tablet coating system of claim 6, wherein the first pressure sensor is inside the pan coater and the second pressure sensor is within external atmosphere.

### Claim 8 (depends on 6)

The tablet coating system of claim 6, wherein the first pressure sensor is upstream of a filter and the second pressure sensor is downstream of the filter.

### Claim 9

A tablet coating system to apply one or more coatings to a tablet, the tablet coating system comprising:
a pan coater operable to apply one or more coatings to the tablet;
a recirculating air handler to supply a humid air flow to the pan coater, the recirculating air handler comprising:
an inlet duct operable to receive exhaust air from the pan coater;
a humidifier to introduce clean steam into the exhaust air in an amount resulting in an exit air having a relative humidity of up to about 94%;
a vent to release air from the recirculating air handler to the atmosphere via a vent valve, wherein the vent valve is opened as needed to maintain an air pressure within the pan coater of at least 0.15 inches of water column below atmospheric pressure; and
an exit duct operable to deliver the exit air to the pan coater;
a flow-through air handler to supply a low humidity air flow to the pan coater, wherein the low humidity air flow has a relative humidity less than the humid air of the recirculating air handler;
one or more ducts and one or more configurable valves, wherein the one or more configurable valves is configured to:
cut off flow through the recirculating air handler and direct the air flow from the flow-through air handler to a supply duct of the pan coater and from an exhaust duct of the pan coater to an exhaust stack; or cut off flow from the flow-through air handler and direct the air flow from exit duct of the recirculating air handler to the supply duct of the pan coater and from the exhaust duct of the pan coater to the inlet duct of the flow-through air handler; and
a control system operable to control the operation of the recirculating air handler and/or the one or more configurable valves.

### Claim 10 (depends on 9)

The tablet coating system of claim 9, wherein the control system comprises a mode control operable to coordinate opening and closing of the one or more configurable valves to switch the air supply of the pan coater from the flow-through air handler to the recirculating air handler.

### Claim 11 (depends on 9)

The tablet coating system of claim 9, further comprising at least one inlet filter situated upstream of the humidifier to remove particulate matter from an airflow entering the recirculating air handler and at least one exit filter situated downstream of the of the humidifier to remove particulate matter from an airflow exiting the recirculating air handler, and wherein the control system further comprises a filter monitor operable to monitor operational status of the inlet and outlet filters within the recirculating air handler and issue warnings to a system user when a filter is clogged and/or in need of cleaning or replacement.

### Claim 12 (depends on 9)

The tablet coating system of claim 9, wherein the control system is further operable to modulate the air flow within the system, modulate temperature within the system, modulate humidity within the system, and/or modulate pressure within the pan coater.

### Claim 13 (depends on 9)

The tablet coating system of claim 9, further comprising:
a heater operable to heat the pan coater;
a temperature sensor operable to measure the temperature of the air flow downstream of the heater, wherein the control system reduces the heat output of the heater if the temperature of the air flow exceeds a maximum temperature; and
a temperature sensor operable to measure air temperature within the pan coater, wherein the control system is operable to command increased heat output by the heater if the air temperature for the pan coater falls below a predetermined threshold temperature.

### Claim 14 (depends on 9)

The tablet coating system of claim 9, further comprising:
a humidity sensor operable to measure humidity introduced by the humidifier, the humidity sensor operatively connected to the exit duct of the recirculating air handler, wherein the control system is operable to increase or decrease the humidifier output if the measured humidity falls outside a minimum or maximum humidity level; and
an additional humidity sensor within the pan coater, wherein the control system is operable to reduce clean steam flow entering the humidifier if the measured humidity at the additional humidity sensor exceeds a predetermined condensation threshold.

### Claim 15 (depends on 9)

The tablet coating system of claim 9, further comprising a first pressure sensor and a second pressure sensor, wherein the control system comprises a pressure monitor operable to monitor a differential pressure between the first pressure sensor and the second pressure sensor and issue an alert or open a venting valve if the differential pressure exceeds a threshold value.

### Claim 16 (depends on 15)

The tablet coating system of claim 15, wherein the first pressure sensor is on the interior of the pan coater and the second pressure sensor is within external atmosphere.

### Claim 17 (depends on 15)

The tablet coating system of claim 15, wherein the first pressure sensor is upstream of a filter and the second pressure sensor is downstream of the filter.