# US 11,076,931 B2 · Capsule for detection of gastrointestinal motility and method for preparing the same

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- Number: US 11,076,931 B2
- Document ID: US11076931B2
- Status: Granted
- Kind: B2
- Application number: 15/635,212
- Filed: 2017-06-28
- Published: 2018-03-01
- Granted: 2021-08-03
- Earliest claimed: 2016-07-27
- Assignees: Ankon Medical Technologies (Shanghai) Co., LTD.
- Applicants: Ankon Medical Technologies (Shanghai), LTD.
- Inventors: Xiaodong Duan; Hongjiao Song; Shaobang Zhang
- Web page: https://patentgrep.com/patent/US11076931B2

## CPC

- A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers}
- A61B 6/12: Arrangements for detecting or locating foreign bodies
- A61B 6/481: {involving the use of contrast agents}
- A61B 6/50: specially adapted for specific body parts; specially adapted for specific clinical applications
- A61K 9/4866: {Organic macromolecular compounds}
- A61K 49/0404: {containing barium sulfate}
- A61K 49/0409: {Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound}
- A61B 2090/3966: {Radiopaque markers visible in an X-ray image}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A capsule for detection of gastrointestinal motility and a method for preparing such a capsule is provided. The capsule comprises a capsule enclosure and a preset quantity of radiopaque markers filled in the capsule. The radiopaque markers further comprise a solid X-ray contrast agent, a medical plastic with a density of at most at 1.4 g/cm3 and an auxiliary agent.

## Claims

### Claim 1

A capsule, comprises
a capsule enclosure and a present quantity of radiopaque markers filled in the capsule, wherein each radiopaque marker comprises
a solid X-ray contrast agent selected from the group consisting of barium sulfate or bismuth salts and—present at least 10% by weight,
a medical grade plastic with a density less than 1.4 g/cm3 present at least 35% by weight,
and an auxiliary agent between 25%-35% by weight,
wherein the capsule is configured to
detect the motility of stomach, small intestine and colon by examining quantity and location of residual radiopaque markers, and wherein the radiopaque markers feature same appearances but different shapes under the X-ray medical images, by having the solid X-ray contrast agents in the radiopaque markers with different shapes or being placed in different locations; and the density of the radiopaque markers is between 1.0-1.7 g/cm3.

### Claim 2 (depends on 1)

The capsule of claim 1, wherein the solid X-ray contrast agent is barium sulfate.

### Claim 3 (depends on 1)

The capsule of claim 1, wherein the weight ratio of barium sulfate in the marker is between 20%-40%, the weight ratio of medical grade plastic is between 35%-45% and the weight ratio of auxiliary agent is between 25%-35%.

### Claim 4 (depends on 1)

The capsule of claim 1, wherein the medical grade plastics is selected from Polyvinyl chloride (PVC), Polystyrene (PS), Polyethylene (PE), Polypropylene (PP), Polycarbonate (PC), or Thermoplastic polyurethanes (TPU).

### Claim 5 (depends on 1)

The capsule of claim 1, wherein the auxiliary agent is selected from lubricants, plasticizers, heat stabilizers, or colorants.

### Claim 6 (depends on 1)

The capsule of claim 1, wherein the radiopaque markers are ring shaped markers whose cross-sections are one of the four shapes including O-ring, Double D, Cross and Tri-chamber.

### Claim 7 (depends on 1)

The capsule of claim 1, wherein the radiopaque markers are ring shaped markers with a cross section of double D which are shown as O-ring, D-ring or E-ring under the X-ray.

### Claim 8 (depends on 1)

The capsule of claim 1, wherein the solid X-ray contrast agent is bismuth salt.

### Claim 9 (depends on 8)

The capsule of claim 8, wherein the weight ratio of bismuth salt in the marker is between 10%-30%, the weight ratio of medical grade plastic is between 45%-55% and the weight ratio of auxiliary agent is between 25%-35%.