# US 11,076,802 B2 · Remote assessment of neurostimulation

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- Number: US 11,076,802 B2
- Document ID: US11076802B2
- Status: Granted
- Kind: B2
- Application number: 17/070,225
- Filed: 2020-10-14
- Published: 2021-03-18
- Granted: 2021-08-03
- Earliest claimed: 2018-04-16
- Assignees: BIOTRONIK SE & Co. KG
- Applicants: Biotronik SE & Co. KG
- Inventors: Lauren Kraiter; Dirk Muessig; Larry Stotts; Andreas Becker
- Web page: https://patentgrep.com/patent/US11076802B2

## CPC

- A61B 5/4848: {Monitoring or testing the effects of treatment, e.g. of medication}
- A61B 5/0004: {characterised by the type of physiological signal transmitted}
- A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet}
- A61B 5/0077: {Devices for viewing the surface of the body, e.g. camera, magnifying lens}
- A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)}
- A61B 5/1116: {Determining posture transitions}
- A61B 5/163: {by tracking eye movement, gaze, or pupil change}
- A61B 5/165: {Evaluating the state of mind, e.g. depression, anxiety}
- A61B 5/42: {Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems (A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence)}
- A61B 5/4266: {sweat secretion}
- A61B 5/442: {Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment}
- A61B 5/4803: {Speech analysis specially adapted for diagnostic purposes}
- A61B 5/4824: {Touch or pain perception evaluation (A61B5/4821 takes precedence)}
- A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)}
- A61B 5/746: {Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms}
- A61N 1/36071: {Pain}
- A61N 1/37247: {User interfaces, e.g. input or presentation means}
- A61N 1/37282: {characterised by communication with experts in remote locations using a network}
- A61B 2562/0238: Optical sensor arrangements for performing transmission measurements on body tissue
- G10L 15/08: Speech classification or search
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- G10L: SPEECH ANALYSIS TECHNIQUES OR SPEECH SYNTHESIS; SPEECH RECOGNITION; SPEECH OR VOICE PROCESSING TECHNIQUES; SPEECH OR AUDIO CODING OR DECODING

## Abstract

The present disclosure relates to a system (1) for remote assessment of a patient (P1), comprising: a first device (2) associated to a physician (P2), a second device (3) associated to the patient (P1), a medical device (4) associated to the patient (P1), wherein the second device (3) is configured to communicate with the medical device (4), and wherein the medical device (4) is configured to be programmed via the second device (3), wherein the first device (2) is further configured to communicate with the second device (3), and wherein the second device (3) is configured to be controlled via the first device (2), and wherein the second device (3) is configured to acquire data (S1, S2) indicative of at least one physiological parameter or of several physiological parameters (HR, F, P) of the patient (P1). Furthermore, a method for remote assessment is provided.

## Claims

### Claim 1

A system (1) for remote assessment of a patient (P1), comprising:
a first device (2) associated to a physician (P2),
a second device (3) associated to the patient (P1), wherein the second device (3) comprises or is connected to a camera (30) that is configured to acquire an optical image or a sequence of optical images (S1) of at least a portion of the patient (P1),
a medical device (4) associated to the patient (P1), wherein the second device (3) is configured to communicate with the medical device (4), and wherein the medical device (4) is configured to be programmed via the second device (3),
wherein the first device (2) is further configured to communicate with the second device (3) and/or with a service center, and wherein the second device (3) is configured to be at least temporarily controlled via the first device (2),
wherein the second device (3) is configured to acquire data (S1, S2) indicative of at least one physiological parameter or of several physiological parameters (HR, F, P) of the patient (P1), wherein said data comprises the optical image or the sequence of optical images (S1), and
wherein the first device (2) and/or the second device (3) and/or the external server is configured to analyze said optical image or sequence of optical images (S1) to determine at least one or several of the following physiological parameters: a perspiration of the patient (P1); a degree of eye opening of the patient (P1); a dilation of the pupils of the patient (P1); a state of a focus of the eyes of the patient (P1); a posture (P) of the patient (P1); the number and/or length of wrinkle lines of the face of the patient (P1) or a quantity derived therefrom,
wherein the first device (2) and/or the second device (3) and/or the external server is configured to calculate a score (PS, Δpain) using said at least one physiological parameter or said several physiological parameters (HR, F, P), and
wherein a baseline pain score is used as a calibration for reporting all assessed pain levels relative to the baseline pain score.

### Claim 2 (depends on 1)

The system according to claim 1, wherein said data further comprises an audio signal (S2) generated by the patient (P1), wherein the second device (3) associated to the patient (P1) comprises or is connected to a microphone (31) that is configured to acquire said audio signal (S2).

### Claim 3 (depends on 2)

The system according to claim 2, wherein the first device (2) and/or the second device (3) and/or the external server is configured to analyze said audio signal (S2) to determine at least one or several of the following physiological parameters: a tonality and/or pattern of speech of the patient (P1); a breathing rate of the patient (P1).

### Claim 4 (depends on 2)

The system according to claim 2, wherein the first device (2), and/or the second device (3) and/or the external server, or a combination thereof, is configured to analyze a signal comprising said optical image or said sequence of optical images (S1) and said audio signal (S2) to determine physiological data.

### Claim 5 (depends on 1)

The system according to claim 1, wherein the medical device (4) is an implantable medical device that is configured to be implanted into the patient (P1).

### Claim 6 (depends on 1)

The system according to claim 1, wherein the medical device (4) is configured for neurostimulation of the patient (P1).

### Claim 7 (depends on 1)

The system according to claim 1, wherein calculation of the score (PS, Δpain) comprises calculation of a weighted sum.

### Claim 8 (depends on 1)

The system according to claim 1, wherein said score (PS, Δpain) is a measure for a physiological state of the patient (P1).

### Claim 9

A method for remote assessment of a patient (P1) using a system (1) according to any one of the preceding claims, wherein data (S1, S2) indicative of at least one physiological parameter (HR, F, P) or of several physiological parameters of the patient (P1) is acquired by the second device (3), wherein said data comprises an optical image or a sequence of optical images (S1) of at least a portion of the patient (P1), and wherein the optical image or the sequence of optical images (S1) is analyzed by the first device (2) and/or the second device (3) and/or the external server so as to determine at least one or several of the following physiological parameters: a perspiration of the patient (P1); a degree of eye opening of the patient (P1); a dilation of the pupils of the patient (P1); a state of a focus of the eyes of the patient (P1); a posture (P) of the patient (P1); the number and/or length of wrinkle lines of the face of the patient (P1) or a quantity derived therefrom;
wherein a score (PS, Δpain) is calculated using said at least one parameter or said several parameters (HR, F, P) by means of the first device (2) and/or the second device (3) and/or the external server.

### Claim 10 (depends on 9)

The method according to claim 9, wherein said data further comprises an audio signal (S2) generated by the patient (P2).

### Claim 11 (depends on 10)

The method according to claim 10, wherein said audio signal (S2) is analyzed by the first device (2) and/or the second device (3) and/or the external server so as to determine at least one or several of the following physiological parameters: a tonality and/or pattern of speech of the patient (P1); a breathing rate of the patient (P1).

### Claim 12 (depends on 9)

The method according to claim 9, wherein particularly said score (PS, Δpain) is a measure for a physiological state of the patient (P1).

### Claim 13 (depends on 3)

The system according to claim 3, wherein the tonality and/or pattern of speech of the patient (P1) is an emotional content in the voice of the patient (P1).

### Claim 14 (depends on 3)

The system according to claim 3, wherein the first device (2) and/or the second device (3) and/or the external server is configured to determine the tonality and/or pattern using a voice analyzing algorithm carried out by the first device.

### Claim 15 (depends on 1)

The system according to claim 1, wherein the second device is formed as a mobile phone or a smart phone.